The present inventions relates to bioresorbable sealing powder comprising: water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups under the formation of a covalent bond; water-soluble nucleophilic cross-linker carrying at least 2 reactive nucleophilic groups that, in the presence of water, are capable of reacting with the reactive electrophilic groups of the electrophilic polymer under the formation of a covalent bond between the electrophilic polymer and the nucleophilic cross-linker; water-absorbing particles containing at least 50% by weight of said water-absorbing particles of water-insoluble polymer containing reactive nucleophilic groups; water-soluble dispersant that is solid at 20 C., said water-soluble dispersant being selected from monosaccharides, disaccharides, oligosaccharides, sugar alcohols and combinations thereof.
wherein the components (a), (b), (c) and (d) may be contained in the same particles or in different particles.

The invention also provides a method of preparing the aforementioned bioresorbable sealing powder

Further provided are (i) a device for powder application comprising the bioresorbable sealing powder, (ii) a biocompatible, flexible, hemostatic sheet comprising the bioresorbable sealing powder and (iii) a kit of parts for preparing a sealing suspension, said kit comprising the bioresorbable powder, and (iv) a sealing suspension containing the bioresorbable sealing powder.

The present inventions relates to bioresorbable sealing powder comprising: water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups under the formation of a covalent bond; water-soluble nucleophilic cross-linker carrying at least 2 reactive nucleophilic groups that, in the presence of water, are capable of reacting with the reactive electrophilic groups of the electrophilic polymer under the formation of a covalent bond between the electrophilic polymer and the nucleophilic cross-linker; water-absorbing particles containing at least 50% by weight of said water-absorbing particles of water-insoluble polymer containing reactive nucleophilic groups; water-soluble dispersant that is solid at 20 C., said water-soluble dispersant being selected from monosaccharides, disaccharides, oligosaccharides, sugar alcohols and combinations thereof.
wherein the components (a), (b), (c) and (d) may be contained in the same particles or in different particles.

The invention also provides a method of preparing the aforementioned bioresorbable sealing powder

Further provided are (i) a device for powder application comprising the bioresorbable sealing powder, (ii) a biocompatible, flexible, hemostatic sheet comprising the bioresorbable sealing powder and (iii) a kit of parts for preparing a sealing suspension, said kit comprising the bioresorbable powder, and (iv) a sealing suspension containing the bioresorbable sealing powder.

A medical method of affixing an element to a surface of dentine, tooth enamel, bone tissue, or corresponding substitute material. The method includes the steps of: providing an attachment composition, the attachment composition having a mixture of: a thermoplastic component; and a hardenable (for example curable) component. The hardenable component is different from the thermoplastic component. The method further includes the steps of: positioning the attachment composition relative to the surface of dentine, tooth enamel, bone tissue, or corresponding substitute material; and activating the attachment composition to attach to the surface or to attach to the element positioned relative to the surface. The step of activating the attachment composition includes activating the attachment composition by means of mechanical vibration.

An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.

An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.

The invention relates to a novel cyanoacrylate medical adhesive and preparation method and application thereof, the main components of the medical adhesive is composed of alkyl cyanoacrylate and/or alkoxy cyanoacrylate and lactyl cyanoacrylate, and by adding a novel stabilizer system, the stability of the novel cyanoacrylate medical adhesive product in the invention increases substantially, the product can be stored and transported at room temperature, degradation performance of the product was greatly improved, the main technical indicators of product such as curing time and mechanical properties can meet the clinical needs, and the user experience of the product such as adhesive film flexibility is greatly improved, so the cyanoacrylate medical adhesive is an widely used surgical hemostatic materials.

The invention relates to a novel cyanoacrylate medical adhesive and preparation method and application thereof, the main components of the medical adhesive is composed of alkyl cyanoacrylate and/or alkoxy cyanoacrylate and lactyl cyanoacrylate, and by adding a novel stabilizer system, the stability of the novel cyanoacrylate medical adhesive product in the invention increases substantially, the product can be stored and transported at room temperature, degradation performance of the product was greatly improved, the main technical indicators of product such as curing time and mechanical properties can meet the clinical needs, and the user experience of the product such as adhesive film flexibility is greatly improved, so the cyanoacrylate medical adhesive is an widely used surgical hemostatic materials.

A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.

A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.

Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.