An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.

An embolization system and methods for controlling solidification of embolic compositions comprising a first and a second embolic component that react with each other in vivo at a target site to form an embolic material, with the embolic components being dilutable in physiological fluids so that they do not form an embolic composition at a site that is not desired.

In some aspects, the present disclosure pertains to a method of forming radiopaque crosslinked hydrogel particles comprising (a) mixing a reactive multi-arm polymer comprising a plurality of cyclic imide ester groups, a reactive multifunctional compound comprising a plurality of amino groups, and a radiocontrast agent under conditions in which a pH environment surrounding the reactive multi-arm polymer, the reactive multifunctional compound and the radiocontrast agent increases from an acidic pH to a basic pH, thereby forming a radiopaque hydrogel and (b) subjecting the hydrogel to a particle size reduction process, thereby forming the radiopaque crosslinked hydrogel particles. Other aspects of the present disclosure pertain to radiopaque crosslinked hydrogel particles formed from such methods, suspensions of such radiopaque crosslinked hydrogel particles, and medical supplies that contain such radiopaque crosslinked hydrogel particles.

In some aspects, the present disclosure pertains to a method of forming radiopaque crosslinked hydrogel particles comprising (a) mixing a reactive multi-arm polymer comprising a plurality of cyclic imide ester groups, a reactive multifunctional compound comprising a plurality of amino groups, and a radiocontrast agent under conditions in which a pH environment surrounding the reactive multi-arm polymer, the reactive multifunctional compound and the radiocontrast agent increases from an acidic pH to a basic pH, thereby forming a radiopaque hydrogel and (b) subjecting the hydrogel to a particle size reduction process, thereby forming the radiopaque crosslinked hydrogel particles. Other aspects of the present disclosure pertain to radiopaque crosslinked hydrogel particles formed from such methods, suspensions of such radiopaque crosslinked hydrogel particles, and medical supplies that contain such radiopaque crosslinked hydrogel particles.

A malleable sustained release formulation is created utilizing a local anesthetic wherein the composition is made sustained release by incorporating it into a bovine or porcine hemostatic agent. The composition is malleable enough to fit into a cavity such as a dental cavity and form the shape of the cavity. In addition to providing sustained release of the anesthetic, the composition also provides quicker reduction in bleeding.

Described herein are polymerizable compositions useful as surgical adhesives, where the compositions include at least one antimicrobial agent dissolved in a cyanoacrylate monomer, where the at least one antimicrobial agent includes povidone iodine and optionally further includes triclosan or a derivative thereof and/or a cinnamon derivative comprising at least one of cinnamaldehyde, a cinnamic ester, or a cinnamon essential oil. The antimicrobial agent is soluble in and compatible with the cyanoacrylate monomer.