A skin compatible component attachable to mammalian skin. The component is formed as a silicone matrix comprising a polyorganosiloxane derived silicone polymer and a moisture control particulate and permeability modifying polymer distributed within the polymer network. The skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peri-stomal skin.

A skin compatible component attachable to mammalian skin. The component is formed as a silicone matrix comprising a polyorganosiloxane derived silicone polymer and a moisture control particulate and permeability modifying polymer distributed within the polymer network. The skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peri-stomal skin.

An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (T.sub.g) of the SMP foam to below 25° C. Other embodiments are described herein.

An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (T.sub.g) of the SMP foam to below 25° C. Other embodiments are described herein.

The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.

The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.

A skin compatible component attachable to mammalian skin. The component is formed as a foamed silicone matrix comprising a polyorganosiloxane derived silicone polymer and moisture control particulate distributed within the polymer network being configured to absorb moisture from the skin. The foamed skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peristomal skin.

A skin compatible component attachable to mammalian skin. The component is formed as a foamed silicone matrix comprising a polyorganosiloxane derived silicone polymer and moisture control particulate distributed within the polymer network being configured to absorb moisture from the skin. The foamed skin compatible component may be utilised as an ostomy wafer or flange to secure an ostomy appliance to the skin and in particular peristomal skin.

The invention relates to a biocompatible, flexible, bone-adhesive sheet that may suitably be applied in the treatment of bone defects, said bone-adhesive sheet comprising: a cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space; distributed within the interstitial space, (i) a plurality of polymer particles comprising a water-soluble calcium-binding polymer, said water-soluble calcium-binding polymer carrying at least one calcium binding group or (ii) a plurality of reactive particles comprising an electrophilically activated water-soluble polymer and a plurality of bisphosphonate particles comprising nitrogenous bisphosphonate.

The invention relates to a biocompatible, flexible, bone-adhesive sheet that may suitably be applied in the treatment of bone defects, said bone-adhesive sheet comprising: a cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space; distributed within the interstitial space, (i) a plurality of polymer particles comprising a water-soluble calcium-binding polymer, said water-soluble calcium-binding polymer carrying at least one calcium binding group or (ii) a plurality of reactive particles comprising an electrophilically activated water-soluble polymer and a plurality of bisphosphonate particles comprising nitrogenous bisphosphonate.