An embodiment of the present disclosure provides an extracellular matrix-based bioadhesive as an adhesive in the form of a composition including an extracellular matrix-containing hydrogel and a gelatin curing agent, wherein the extracellular matrix-containing hydrogel is gelatinized. Since the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure has the same or similar rheological properties as gelatin, the bioadhesive has flowability at a temperature of 30 C. or higher and may be evenly and easily applied to a lesion site in the body. In addition, the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure may adhere well to the lesion site because of a level of adhesive strength that is about 2 to 6 times higher than that of fibrin glue used as a commercial tissue adhesive. In addition, the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure is based on a tissue-derived extracellular matrix, and thus includes a tissue-derived wound healing component or a tissue regeneration component, and may be used for wound healing or tissue regeneration in addition to bioadhesive applications.

Delivery devices, delivery systems, and related methods, for precise administration of hemostatic compositions are disclosed, which may include a trigger mechanism, a pusher, a valve, and a cannula. The pusher is configured to engage with the trigger mechanism, retain a first syringe, a least by coupling with a plunger of the first syringe. The valve is fluidly coupled to the first syringe. The valve is further configured to engage with a second syringe, in fluid communication with both the valve and the first syringe. The cannula extends distally from and is fluidly coupled to the valve. Activation of the trigger mechanism causes the pusher and the plunger of the first syringe to translate in a distal direction, to expel a composition out of the first syringe, through the valve, through the cannula, and out of a distal end of the cannula.

A hemostatic sponge comprising crosslinked gelatin and/or gelatin/chitosan, a method for manufacturing it, and methods of its use.

Delivery devices, delivery systems, and related methods, for precise administration of hemostatic compositions are disclosed, which may include a trigger mechanism, a pusher, a valve, and a cannula. The pusher is configured to engage with the trigger mechanism, retain a first syringe, a least by coupling with a plunger of the first syringe. The valve is fluidly coupled to the first syringe. The valve is further configured to engage with a second syringe, in fluid communication with both the valve and the first syringe. The cannula extends distally from and is fluidly coupled to the valve. Activation of the trigger mechanism causes the pusher and the plunger of the first syringe to translate in a distal direction, to expel a composition out of the first syringe, through the valve, through the cannula, and out of a distal end of the cannula.

The present invention provides a kit for preparing a composition for sealing a lung tract, comprising: (a) a first component comprising: (i) a fibrinogen solution, and (ii) prewet gelatin particles in an aqueous solution; and (b) a second component comprising: (i) a thrombin solution, and (ii) a dry gelatin powder; wherein the first and second components are stored separately and configured for mixing together to form a composition that is flowable and cross-linkable. The composition may be used to seal tissue tracts such as lung tissue tracts.

Provided are a biomedical tape, a preparation method thereof and use thereof. The biomedical tape comprises a hydrogel carrier in dry state and a functional nanomaterial encapsulated within the hydrogel carrier in dry state, and the hydrogel carrier in dry state comprises a thin film body of hyaluronic acid hydrogel and a dopamine-modified polyacrylic acid permeated into a surface of the thin film body of hyaluronic acid hydrogel. The preparation method for the biomedical tape comprises: preparing a hyaluronic acid hydrogel with the functional nanomaterial dispersed therein, and drying and curing the hydrogel to form a film to obtain the thin film body of hyaluronic acid hydrogel; and preparing a dopamine-modified polyacrylic acid solution, and permeating the solution into a surface of the thin film body of hyaluronic acid hydrogel by coating to obtain the biomedical tape.

Provided is a hemostatic dressing. The hemostatic dressing includes: a porous matrix layer including a biocompatible polymer; a hemostatic layer loaded on the porous matrix layer and including a polymer in which polyhydric phenol-containing moieties are introduced; and a binding layer interposed between the porous matrix layer and the hemostatic layer to prevent the porous matrix layer from being separated from the hemostatic layer.

Embolic particles of salted thermally crosslinked gelatin provide for temporary embolization for vessels within a patient. The embolic particles may be formed by drying a gel or liquid layer of gelatin and salt to form a dry salted gelatin sheet which can then be milled and sieved to a selected particle size range. The embolic particles may be characterized as a collection of particles with a majority of the particles having a platelet shape or ellipsoidal shape with a thickness or dimension no more than about 2000 microns. Useful sieved particle sizes include from 63 microns to 250 microns, or less than 63 microns. Methods of making the embolic particles from sheets of dry salted thermally crosslinked gelatin are described, as are methods for making the sheets. Methods and medical systems for performing temporary occlusion of a blood vessel are also described.

Adhesive compositions including a multivalent metal salt, an multidentate acidic organic compound, and an aqueous medium are disclosed. The multivalent metal salt and multidentate acidic organic compound can include, as a mixture, a carbonate salt and/or carbonic acid. The aqueous medium can include pH adjusting agent such as sodium hydroxide. The adhesive composition, upon curing, can have a porosity of 10-50%. The adhesive composition, upon curing, can include a plurality of pores. The adhesive composition can be porous, and upon curing can have a plurality of pores having a pore size of between 20 m to 200 m. Methods of producing the adhesive composition are disclosed. Methods of using the adhesive composition are further disclosed.

An injectable and temperature-responsive enhanced composite dual-network magnetic particle gel is a hydrogel, including a particle gel network formed by gelatin nanoparticles and Fe.sub.3O.sub.4 nanoparticles via an electrostatic interaction and a poly(N-isopropylacrylamide) (PNIPAM)-based temperature-sensitive polymer gel network. At room temperature, the hydrogel exhibits excellent shear-thinning and self-healing properties, and is easily injectable through needles and microcatheters. When raised to a human body temperature (37 C.), the temperature-sensitive polymer undergoes phase transition cross-linking, enhancing mechanical properties of the gel network. The hydrogel is injectable in vitro and exhibits temperature-responsive strengthening in vivo, meeting the requirements of a vascular interventional embolization material. The hydrogel can also generate magnetothermal heating under an alternating magnetic field, thereby achieving the embolization combined with magnetothermal therapy for liver cancer. The preparation method is simple, with high biocompatibility and a great potential for clinical applications.