A shape memory adhesive material for adhering and contracting wounds, particularly diabetic wounds, to facilitate their closure and healing. The shape memory adhesive is pre-stretched and dried to provide an adhesive structure with a pre-programmed strain, wherein the adhesive is capable of rapid robust adhesion followed by predictive contraction upon contact with a wet surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.

A system and method are disclosed for monitoring a wound for infection with a pH-sensitive wound dressing. In one aspect, a method for monitoring a wound for infection involves the steps of positioning a pH-sensitive wound dressing in direct contact with the wound, maintaining contact between the pH-sensitive wound dressing and the wound for an observation period, and evaluating whether the pH-sensitive wound dressing reflects a colorimetric change during the observation period. The pH-sensitive wound dressing includes a hydrogel configured for contact with the wound, a pH-indicating dye that is incorporated within the hydrogel, and a hydrogel covering configured to maintain contact between the hydrogel and the wound. The pH-indicating dye demonstrates the colorimetric change within a pre-determined pH range.

The present disclosure relates to haemostatic compositions comprising a biocompatible polymer, thrombin and fibrinogen and methods for the preparation of such compositions.

Disclosed herein is a method of manufacturing hemostatic particles, which involves heating and mixing a chitosan solution and a gelatin solution to form a chitosan/gelatin solution, adding the chitosan/gelatin mixture to oil containing an emulsifier/surfactant to form a combination of chitosan/gelatin and oil, heating and mixing the combination and then cooling and stirring the combination to form gelatin-chitosan microspheres (GCM), adding an aqueous solution of glutaraldehyde to the combination and stirring to cross-link the GCM, washing the GCM with emulsifier/surfactant to remove the oil, washing the GCM with a solvent to further remove excess oil, washing the GCM with alcohol to remove excess water, and drying the GCM.