The present invention relates to a composition comprising a protein fibril scaffold, wherein the composition permits the attachment and extended release of agents such as biologically active agents, and thus has numerous applications, including in skin care and in wound care.

A water-soluble sealant composition and a method for preparing the same which includes: adding soluble silver salt to a polyacrylic acid (PAA) solution; adjusting the pH of the PAA solution to 7-7.4; and heating the PAA solution to 90-125° C. The PAA has a molecular weight between 1000 to 8000. The composition includes a cross-linked poly(acrylic) silver matrix having affinity to proteins. The silver salt can be silver nitrate and/or silver acetate. The matrix may create hydrophilic zones which bind proteins. The composition when in contact with proteins may form hexagonal packing complexes of rod-like poly(acrylic) particles and proteins. It may form a clot made of multi-layered grid structure. In some cases, the complexes create loops that form cells comprising proteins e.g., albumin. The proteins may be of a body fluid such as blood, lymph and combinations thereof. The composition may be applied for a medical condition such as hemorrhage and lymphorrhea.

The present invention relates to an antimicrobial pharmaceutical composition, comprising an aqueous carrier, and an antimicrobial synthetic cationic polypeptide(s) dispersed in the aqueous carrier at a concentration in the range of about 0.01% to about 5%, by weight based on total weight of the antimicrobial pharmaceutical composition, wherein the antimicrobial synthetic cationic polypeptide(s) comprises a plurality of positively charged amino acid units at neutral pH, and fulfils certain viscosity and toxicity requirements. The invention further relates to a method of preventing microbial contamination of tissues other than intact, healthy skin, comprising administering the present antimicrobial pharmaceutical composition in an amount effective to at least partially protect the tissue site from becoming contaminated with microbes.

The present invention provides a liquid band-aid containing peptide anti-inflammatory active ingredient and a preparation method thereof, which belong to the technical field of medical materials. The liquid band-aid includes film-forming agent, plasticizer, anti-inflammatory substance, and solvent, where the plasticizer includes glycerin, the solvent includes deionized water, and the anti-inflammatory substance includes high F-value oligopeptide with an amino acid sequence of Leu-Leu-Phe-Thr-Thr-Gln and a molecular weight of 736.52 Da. The liquid band-aid can promote the expression of interleukin 10 (IL-10) and inhibit the expressions of cytokine interleukin 6 (IL-6) and tumor necrosis factor (TNF-α), and thus have good anti-inflammatory activity. The liquid band-aid further enhances the close contact between gel and an injured skin surface, increases the cleanliness of a wound surface, and improves the clearance rate of inflammatory cells.

A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.

Described are nanogels suitable for scaffolds for encapsulating human dermal fibroblasts for non-healing chronic wounds. Peptide nanogels Ac-IVZK-NH.sub.2 and Ac-IVFK-NH.sub.2 are selected and produce silver nanoparticles in situ within the nanogels to assess their efficacy on micropigs with full-thickness excision wounds. The in situ generation of the silver nanoparticles is done solely through UV irradiation and no reducing agent is used. Application of the peptide nanogels on full thickness micropig wounds demonstrate that the scaffolds are biocompatible and do not trigger wound inflammation. This suggests that scaffolds are safe for topical application. A comparison of the effect of both nanogels even without the addition of the silver nanoparticles, reveals that the scaffold itself has a high potential as an antibacterial agent, which may suppress both the inflammatory reaction and the activity of proteases. The effect on wound closure of the peptide nanogels is comparable to standard care hydrogels.

The present invention relates to in vitro cultured senescent cells, such as epithelial cells, keratinocytes and/or fibroblasts as well as their use in the treatment of tissue regeneration, particularly for the treatment of wounds such as burns or ulcers or the treatment of inflammatory conditions. Optionally, products may be used in combination with further drugs including antimicrobial or antidiabetic agents.

Meshes for use to control the movement of bodily fluids, such as blood, are described herein. The mesh can be partially or completely biodegradable or non-biodegradable. In one embodiment, the mesh is formed from one or more self-assembling peptides. The peptides can be in the form of fibers, such as nanofibers. The peptides can be assembled prior to formation of the mesh or after the mesh has been formed but before it is applied. Alternatively, the mesh can be prepared from unassembled peptides, which assemble at the time of application. The peptides can assemble upon contact with bodily fluids (e.g., blood) or can be contacted with an ionic solution to initiate assembly.

Methods are provided to produce optimal fractionations of charged keratins that have superior biomedical activity. Also provided are medical implants coated with these keratin preparations. Further provided are methods of treating blood coagulation in a patient in need thereof.

The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.