The invention relates to a method for surface treatment of a biocompatible metal material, such as an implant, which comprises the following consecutive steps: i) abrasive mechanical treatment of the surface of said material using abrasive calcium phosphate grains, such as a mixture of hydroxyapatite and tricalcium phosphate; ii) acid treatment by hot dipping of said material in a bath comprising sulphuric acid and hydrochloric acid, followed by at least one rinse with demineralised water; iii) sodic treatment by hot dipping of said material in a soda bath followed by at least one rinse with demineralised water and drying in hot air. The implant thus treated has a surface with increased roughness with a triple level of porosity (macro-, micro- and nano-porosity) as well as improved hydrophilic properties. The method can be used for implants made of titanium alloys, such as the TA6V ELI alloy.

A more versatile and anatomically correct breast implant is described. The breast implant comprises a container filled with a liquid or gel filling material and a support member coupled to the container, wherein the support member is an integral part of the container.

Provided are an iron-based absorbable and implantable medical device and manufacturing method thereof. The iron-based absorbable and implantable medical device (1) comprises a substrate (11), a degradable polymer layer (12), and an anionic surfactant layer (13) located between the substrate (11) and the degradable polymer layer (12). The anionic surfactant, by using the hydrophobicity thereof, can form a hydrophobic barrier layer in a solution to isolate a surface of the iron-based substrate (11) from a body fluid environment, thereby avoiding direct contact with an acidic environment resulting from degradation of the degradable polymer layer (12) at the initial and early stages of implantation, thus preventing severe local corrosion of the iron-based substrate (11).

A magnetic biomolecule-metal ion self-assembly complex for treatment includes an iron ion; and at least one ligand, wherein the ligand and the iron ion are reversibly self-assembled with each other or self-disassembled from each other, wherein the ligand and the iron ion are self-assembled with each other via a first bond to form a self-assembly, wherein the self-assembling is performed by at least one of the metal ion and the ligand, wherein the self-assembly includes a plural of self-assemblies, wherein the self-assemblies adjacent to each other self-bind to each other via a second bond to form the self-assembly complex. The magnetic biomolecule-metal ion self-assembly complex is effectively used for cancer treatment, osteoarthritis treatment, and bone defect treatment.

An iron-based alloy absorbable and implantable medical device for internal fixation. A substrate includes an iron-based alloy and degradable polymer. The mass ratio of the iron-based alloy to the degradable polymer is between 1:4 and 4:1. The weight-average molecular weight of the degradable polymer is between 150000 to 3000000, and the polydispersity index thereof is between 1 and 6. The device further includes antioxidants. The iron-based alloy is used as a load-bearing framework or reinforcement phase of the device. By adjusting the mass ratio of the iron-based alloy to the degradable polymer and the combination mode thereof, the corrosion rate of the iron-based alloy in the late period of the implantation is accelerated, and the quantity of corrosion products poorly soluble in the iron-based alloy is reduced. Adding antioxidants to the device further reduces the quantity of the corrosion products poorly soluble in the iron-based alloy.

Disclosed are an absorbable iron-based alloy implanted medical device (1) and preparation method thereof. The device (1) comprises an iron-based alloy base (11), a degradable polymer (13) arranged on the surface of the iron-based alloy base, and an alkaline protector (12) arranged on the surface of the iron-based alloy base. The alkaline protector (12) contains at least one alkaline substance capable of neutralizing the acidic substance produced by the polymer at the early stage after the device is implanted to delay the corrosion of the iron-based alloy base (1) in the early stage of implantation, hence the iron-based alloy base (12) would not substantially corrode or would corrode slowly, clinically satisfying the mechanical properties and requirements of the device (1) in the early stage of implantation; and in the meantime, after the neutralization and consumption of the alkaline protector (12) exposes the base (11), the base (11) can still accelerate the corrosion speed thereof in the acidic environment formed by the polymer (13), so as to clinically satisfy the requirement of the corrosion cycle of the device (1) at the same time.

Absorbable iron-based alloy implanted medical device and manufacturing method thereof. The iron-based alloy implanted medical device comprises an iron-based alloy substrate (11), a degradable polymer layer (13) disposed on a surface of the iron-based alloy substrate (11), and a tannic acid chemical conversion film (12) disposed on a surface of the iron-based alloy substrate (11). After the medical device is implanted into a body, the tannic acid chemical conversion film (12) is configured to protect the iron-based alloy substrate (11) coated thereby from being in contact with a body fluid, thereby ensuring that the device meets a clinical mechanical property requirement in the early stage of implantation. Furthermore, the iron-based alloy implanted medical device has a decreased size, and produces a decreased amount of a corrosive product after being implanted, facilitating faster absorption or elimination of the corrosive product.

An absorbable implantable medical device made of iron-based alloy, including a base made of iron-based alloy and a complex, wherein the complex includes a complexing agent. In a physiological solution, the base made of iron-based alloy can react with the complexing agent to generate a water-soluble iron complex having solubility in the physiological solution of no less than 10 mg/L. A corrosion product generated after the absorbable implantable medical device made of iron-based alloy is implanted in a human body can be quickly metabolized/absorbed by the body.

An absorbable iron-based alloy implantable medical device includes an iron-based alloy matrix, a degradable polymer coating disposed on the surface of the iron-based alloy matrix, and a corrosion inhibition layer disposed on the surface of the iron-based alloy matrix. The corrosion inhibition layer can delay early-stage corrosion of the iron-based alloy matrix, ensure mechanical performance of a medical device in the early stage of the implantation, prevent degradation of a polymer in the early stage of the implantation of the medical device, and reduce the usage of the degradable polymer, thereby reducing risks of inflammatory reactions.

An iron based and absorbable implanted prefabricated tube (1) for medical device and preparation method therefor, and a medical device prepared by the prefabricated tube and preparation method therefor. The average nitrogen content of nitrogen in the prefabricated tube is from 0.04-0.4 wt. % or 0.02-0.04 wt. %. The prefabricated tube can be cut along the length direction directly by laser or by machining to obtain multiple absorbable implanted medical devices.