Disclosed is a medical device (9) comprising a porous structure (1), wherein a configuration of the porous structure (1) varies in dependence on a load applied to the porous structure (1), such that the porous structure (1) has a first configuration when the load is of a first magnitude, and has a second configuration when the load is of a second magnitude greater than the first magnitude. The porous structure (1) comprises a first surface portion (2) and a second surface portion (3). The first surface portion (2) is disengaged from the second surface portion (3) when the porous structure (1) has the first configuration, and is engaged with the second surface (3) portion when the porous structure (1) has the second configuration.

An ossicular prosthesis has a head plate as a first fastening element, a second fastening element for the mechanical connection to the ossicular chain, or to the inner ear, and a connecting element. The head plate has a central coupling region and radially outward extending bridging elements which are connected to the coupling region via a radially inner end region and each transition into an outer free end section. The bridging elements are connected to the coupling region so that they fold together upon introduction of a force component parallel to the longitudinal axis, wherein their end sections are pivoted radially closer to the longitudinal axis and thereby also execute an axial movement. The bridging elements, without this force, extend from the coupling region at a predefined, fixed angle. The prosthesis can be inserted into the middle ear of the patient more easily and through a much smaller artificial opening.

A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.

The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.

Implementations described herein provide for junctionless monolithic composite implants and methods for manufacturing the same. The implant includes a monolithic composite body having a first region comprising a first metal alloy, a second region comprising a second metal alloy, and a transition region disposed between the first region and the second region formed from a bonded mixture of the first alloy and the second alloy. In one example, the transition region is a sintered mixture of the first alloy and the second alloy. In another example, the transition region is disposed at a region of minimum stress within the monolithic composite body under physiological loading conditions of the implant.

An implant comprises a substrate and a coating on a surface of the substrate, and the coating includes silicon nitride and has a thickness of from about 1 to about 15 micrometer wherein the silicon nitride coating has a composition defined by Si.sub.xN.sub.yW.sub.z, where W is C, H and/or O, 2<x<4, 3<y<5, and z is such that the coating contains less than 20 atomic percent of C, H and O.

A device, for example a medical implant, and a method of making the same, the device having a metal or metal alloy substrate, for example cobalt chrome, and a diffusion hardened metallic surface, for example a plasma carburized surface, contacting a non-diffusion hardened surface or a diffusion hardened surface having a diffusion hardening species different from that of the opposing surface.

A method of forming prefabricated units used in production of systems of prosthetic aortic valve transcatheter implantation and prosthetic aortic valve prefabricated unit with an non-thrombogenic smooth surface layer or with a porous fibrous layer constituting a scaffold for epithelium cell culture, intended for manufacturing TAVI system. Stents for covering and solutions of polycarbonate silicones and/or polycarbonate urethanes and/or polyurethane with average molecular weight in the range from 50 000 g/mol to 200 000 g/mol in the solvent DMAC are prepared. Initially a smooth layer of polycarbonate silicone is applied in the electrospinning machine by electrospraying with use of the solution in DMAC with the concentration of 2-8% w/w. and/or a fiber of polycarbonate urethane is applied by electrospinning on the roller with use of the solution in DMAC with the concentration of 8-20% w/w to obtain the first surface layer, with a specified speed, number of heads, thickness of capillaries, speed of movement, voltage and distance between the capillary and the roller and the specified flow of the solution on the feeding pump and after a certain time the layer covering the roller with thickness of 1-100 m is obtained. Thereafter the inner intermediate layer of polycarbonate silicone is formed by electrospraying. When the thickness of the layer is approximately 5 to 100 m the process is stopped and stents are placed on the formed layer and similarly like applying the former intermediate layer the application of the inner intermediate layer is continued on the whole length of the roller. Thereafter the final surface layer is applied like the first surface layer until a prefabricated unit with the polymer material thickness from 50 to 250 m is obtained.

Joint resurfacing and/or replacement devices, systems and methods that include thin film ternary ceramic coatings that are effective to provide reliable articulation and bearing surfaces and protection of both articular and modular junction surfaces from the potential for corrosion, wear, and fretting, and reduce the potential for release of metal ions from the joint systems. Isoelasticity is provided according to the particular joint resurfacing/replacement devices, systems and methods based on parameters that include material of construction, porosity and coating system. The thin film ternary ceramic coatings may be functionalized to enhance hydrophilicity and may be employed in any anatomical articulating joint region. Titanium alloy composite structures are provided that include an ultra-porous structured titanium alloy bone fixation surface and an opposed solid articular surface and a thin film ternary ceramic coating applied to one or both opposed surfaces.

Joint resurfacing and/or replacement devices, systems and methods that include thin film ternary ceramic coatings that are effective to provide reliable articulation and bearing surfaces and protection of both articular and modular junction surfaces from the potential for corrosion, wear, and fretting, and reduce the potential for release of metal ions from the joint systems. Isoelasticity is provided according to the particular joint resurfacing/replacement devices, systems and methods based on parameters that include material of construction, porosity and coating system. The thin film ternary ceramic coatings may be functionalized to enhance hydrophilicity and may be employed in any anatomical articulating joint region. Titanium alloy composite structures are provided that include an ultra-porous structured titanium alloy bone fixation surface and an opposed solid articular surface and a thin film ternary ceramic coating applied to one or both opposed surfaces.