The invention relates to a biodegradable implant comprising a surface coated magnesium alloy or zinc alloy product, whereby the coating layer comprises oxides and/or phosphates of from rare-earth elements, Mg, Ca, Zn, Zr, Cu, Fe, Sr, Li, Mn or Ag wherein the coating is preferably generated by plasma electrolytically oxidation (PEO). The invention further comprises a method for preparing the coated magnesium or zinc alloy product of the implant.

Metal objects are treated by anodising the metal object in contact with an aqueous electrolyte, and then subjecting the anodised metal object to a reversed voltage. The anodising is performed in two stages, firstly to passivate with the formation of an oxide layer, and secondly to form regions in the oxide layer having a higher oxygen to metal atom ratio, for example pits or caps, in this oxide layer. The second stage of anodising is performed by applying a multiplicity of voltage cycles, each voltage cycle involving ramping the voltage between a lower threshold voltage and an upper threshold voltage, and then returning to the lower threshold voltage. The reversed voltage step forms a hydrous metal oxide in the regions of higher oxygen to metal atom ratio, and the oxide layer and hydrous metal oxide together constitute a surface layer which is integral with the metal object, and has ion exchange capacity. After the reversed voltage step the metal object is then contacted with a bio-effective material such as a biocidal metal, which is absorbed into the surface of the metal object. The processing time may be reduced by applying the multiple voltage cycles. The invention also provides a treated metal object which can be prepared by treating a metal object having a micro-rough surface according to the method described above.

A bioabsorbable implant for non-luminal region comprising: a core structure including a magnesium alloy having a predetermined shape; a first corrosion-resistant layer containing a magnesium fluoride layer as a main component formed on the core structure via fluorination of a surface of the magnesium alloy; and a second corrosion-resistant layer containing a parylene formed on the magnesium fluoride layer.

Provided are tissue repair and sealing devices, and methods for the use of tissue repair and sealing devices, for use in both minimally invasive surgical (MIS) procedures and open, non-MIS procedures to rapidly repair tissue fenestrations and create a pressure-resistant, watertight seal in a tissue barrier. Tissue repair and sealing devices disclosed herein comprise an integrated graft and deployable clasp assembly and an applicator assembly having a clasp retain and release member that is slidably connected to a folded, deployable clasp. The applicator assembly places a graft on a tissue inner surface and a deployable clasp on a tissue outer surface to secure the graft to the tissue inner surface to, thereby, repair a tissue fenestration and create a watertight barrier.

A hybrid scaffold is disclosed which is made of materials that define peripheral layers designed to interface with the tissues in the implant site and one or more intermediate layers. The materials are combined to give the scaffold mechanical properties suitable for withstanding the stresses of the implant site. The materials are fibroin for the peripheral layers and polyurethane combined with fibroin for each intermediate layer.

An implant, preferably for treating and/or reconstructing, in particular lining and/or sealing and/or relining and/or at least partially filling an acetabular defect, having at least one flat structure which contains a material that is at least partially decomposable or resorbable in vivo. The invention further relates to a surgical kit and the use of an unfinished flat structure for producing an implant.

An implant comprises a metal body having a ceramic coating comprising monoclinic and orthorhombic phases of zirconium oxide ZrO2 and at least one multi-metal phosphate from the group comprising l-IV metal phosphates. A method of forming an implant is provided. A method of applying a ceramic coating to a metal body comprises the step of electrochemical oxidation of at least a portion of the surface of a metal body in aqueous electrolyte; in which the electrolyte contains at least two elements from a group consisting of zirconium, titanium, magnesium, phosphorus, calcium, fluoride, potassium, sodium, strontium, sulphur, argentum, zinc, copper, silicon, gallium; in which electrochemical oxidation is conducted in a plasma discharge (PEO) mode for at least one interval of time, and non-discharge modes for at least two intervals of time.

A medical device and a method and process for at least partially forming a medical device, which medical device has improved physical properties.

The present disclosure discloses a zonal trabecular uni-compartmental femoral condylar component containing zirconium-niobium alloy on oxidation layer and preparation method, including following steps: using zirconium niobium alloy powder as raw material, conducting a 3D printing for one-piece molding to obtain an intermediate product of the uni-compartmental femoral condylar component, performing hot isostatic pressing and cryogenic oxidation to obtain the uni-compartmental femoral condylar component; the uni-compartmental femoral condylar component includes an articular surface and an osseointegration surface, a bone trabeculae is arranged on the osseointegration surface. The present invention can reduce the fretting wear of the interface between the prosthesis and the bone, and reduce the stress shielding effect of the prosthesis on the bone tissue, homogenize the stress of the femoral condylar bone tissue, and improve the initial stability and long-term stability of the uni-compartmental femoral condylar component.

A photocrosslinkable agent includes at least one methacrylate-modified nanoparticle that includes a plurality of molecules attached to surface of a nanoparticle. At least a portion of the molecules includes a molecule that includes a nanoparticle surface attachment ligand a terminal methacrylate ligand. At least a portion of the molecules may include a second molecule that includes a nanoparticle surface attachment ligand and a hydrophilic terminal ligand, wherein the methacrylate-modified nanoparticle has water solubility that is controlled by the relative amounts of the terminal methacrylate ligand and the hydrophilic terminal ligand. The photocrosslinkable agent may be crosslinked within a polymer network by a one-step process, with minimal disruption to the molecular network or crosslinking density and may be formulated for use as one or more of an imaging contrast agent, a therapeutic, or a reinforcement, a transducer.