The invention relates to a method and a device for producing an implant, wherein a natural bone microstructure of a natural bone region is detected (S1), an implant region in the natural bone region is marked (S2), the detected bone microstructure in the marked implant region is analysed to determine reproduction parameters (S3), and on the basis of the determined reproduction parameters, an artificial microstructure for producing the implant is created (S4).

Provided is a bone regenerative agent which can repair a bone defect site with preventing from remaining at the bone defect site. The bone regenerative agent comprises zinc subcarbonate containing hydrozincite. It is preferred that the zinc subcarbonate has a Zn2+ ion elution amount of 0.1 ppm by mass or more after an elution test and also has a pH value of 7.2 or more and less than 8.3 after an elution test. It is preferred that some carbonate ions in the hydrozincite are substituted by sulfate ions or chloride ions. It is preferred that the bone regenerative agent is applied to a bone defect site.

The present invention relates in part to a hydrogel composition and a method of fabricating the hydrogel composition comprising the steps of providing a solution comprising a polymer comprising crosslinkable groups; providing a solution comprising a crosslinking agent; mixing the solution comprising a polymer comprising crosslinkable groups and the solution comprising the crosslinking agent to form a combined solution; and crosslinking the combined solution. The invention also relates in part to a methods of treatment using the hydrogel composition.

An annuloplasty ring prosthesis comprising a frame having an outer surface; and a cover surrounding the frame. The cover comprises a bioprosthetic tissue that can be regenerative or fixed and non-regenerative. The frame can be bioabsorbable or non-degradable. A ring prosthesis and a method of manufacturing a ring prosthesis is also provided. The ring prosthesis comprising an elongated rod member formed into a substantially ring shape, the elongated rod member being formed substantially from a flat bioprosthetic tissue.

The present invention relates to a glass ceramic composition comprising SiO.sub.2, Ca(OH).sub.2, CaF.sub.2, B.sub.2O.sub.3, MgO, and hydroxyapatite; a bioactive crystallized glass ceramic comprising each of CaSiO.sub.3, Ca.sub.10(PO.sub.4).sub.6(OH).sub.2, and CaMgSi.sub.2O.sub.6 in an amount of 20% to 60% by weight; an implant for early osseointegration comprising the glass ceramic; and a method for manufacturing the implant.

Disclosed herein are methods for functionalizing the surface of a biomedical implant. The biomedical implant may be a zirconia-toughened alumina implant surface functionalized with silicon nitride powder for promoting osteogenesis.

The present invention provides a method of nerve repair using localized delivery of heat. The method involves localized induction of hyperthermia for end-to-end attachment of severed peripheral nerves by delivering stimulus responsive materials and exposing them to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the nerve ends.

The present invention relates to a dental implant that contains a metal-organic framework (MOF) structure involving antibacterial metal ions, especially silver (Ag), thus can release long-term and controlled antibacterial metal ions and exhibits a long-term antibacterial/antimicrobial effect, has osseointegration capability and high biocompatibility and a method for preparing this dental implant.

A method of forming a gel particle slurry includes providing a first solution that includes a cross-linkable hydrogel polymer macromer and an optional first crosslinker in a first depot and optionally a second solution in a second depot that is separated from the first depot by a mixing unit that includes a mixing element; and reversibly transferring the first solution and the optional second solution through the mixing unit between the first depot and the second depot such that the first solution and the optional second solution are mixed and agitated to form the gel particle slurry.

Provided are tissue repair and sealing devices, and methods for the use of tissue repair and sealing devices, for use in both minimally invasive surgical (MIS) procedures and open, non-MIS procedures to rapidly repair tissue fenestrations and create a pressure-resistant, watertight seal in a tissue barrier. Tissue repair and sealing devices disclosed herein comprise an integrated graft and deployable clasp assembly and an applicator assembly having a clasp retain and release member that is slidably connected to a folded, deployable clasp. The applicator assembly places a graft on a tissue inner surface and a deployable clasp on a tissue outer surface to secure the graft to the tissue inner surface to, thereby, repair a tissue fenestration and create a watertight barrier.