Provided herein is a prosthetic heart valve device including a biocompatible and biodegradable metal frame comprising a proximal end, a distal end, and a sidewall therebetween, the sidewall having a plurality of openings therethrough. The device further includes a biocompatible and biodegradable polymeric heart valve having an annular portion attached at least one contact point to the proximal end of the frame and at least one leaflet attached to and extending distally from the annular portion.

A stent-graft apparatus includes a membrane configured to exhibit one or more mechanical properties in a range corresponding to a range for the one or more mechanical properties for human vascular tissue, and a scaffold coupled to the membrane, the scaffold including one or more struts.

The present invention relates to a viscoelastic agent that is suitable for ophthalmic surgery and can avoid the problem of intraocular lens opacity after ophthalmic surgery (such as cataract surgery). The viscoelastic agent comprises viscoelastic substance(s), pH buffering agent(s), wherein the pH buffering agent is selected from pH buffering agent(s) based on boric acid and/or borate, osmotic pressure regulator(s), and water. The viscoelastic agent may further optionally comprise substances with oxidizing and/or reducing properties.

Provided are tissue repair and sealing devices, and methods for the use of tissue repair and sealing devices, for use in both minimally invasive surgical (MIS) procedures and open, non-MIS procedures to rapidly repair tissue fenestrations and create a pressure-resistant, watertight seal in a tissue barrier. Tissue repair and sealing devices disclosed herein comprise an integrated graft and deployable clasp assembly and an applicator assembly having a clasp retain and release member that is slidably connected to a folded, deployable clasp. The applicator assembly places a graft on a tissue inner surface and a deployable clasp on a tissue outer surface to secure the graft to the tissue inner surface to, thereby, repair a tissue fenestration and create a watertight barrier.

Medical devices, such as implants, having a high-modulus alloy. The alloy includes a biocompatible refractory-metal-based alloy having multiple refractory metals. The alloy in various embodiments has an elastic modulus above about 300 GPa, and includes tungsten, molybdenum, and tungsten.

A dental implant and a method of dental restoration. In one embodiment, the dental implant includes at least one root adapted to be inserted into a hole of a mandibular bone or a maxillary bone, and an abutment on top of the root adapted to mate with a crown. Each root may be a lattice scaffold configured to house bone grafting material. A bone grafting material may be inserted within the lattice scaffold to occupy vacant space within the root and the hole of the mandible/maxilla. A method of dental restoration may include obtaining an image of at least a portion of a mandibular bone or a maxillary bone of a patient, drilling a hole into the mandibular bone or maxillary bone, inserting a one-piece dental implant with an abutment and one or more non-threaded roots into the hole, and installing a crown on the abutment of the one-piece dental implant.

A method for producing a magnesium alloy having improved mechanical and electrochemical properties. The method includes generating a high-purity magnesium by vacuum distillation. A billet of the alloy is generated by synthesis of the high-purity magnesium with 2.0 to 10.0% by weight Al, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases, in a total amount of no more than 0.0063% by weight of Fe, Si, Mn, Co, Ni, Cu, Zr, Y, Sc or rare earths having the ordinal numbers 21, 57 to 71 and 89 to 103, Be, Cd, In, Sn and/or Pb as well as P, wherein the matrix of the alloy includes intermetallic phases formed of Mg and Al. The alloy is homogenized by annealing at a temperature between 150° C. and 450° C. The homogenized alloy is formed in the temperature range between 200° C. and 400° C.

A biomedical implant (16, 18) is formed from magnesium (Mg) single crystal (10). The biomedical implant (16, 18) may be biodegradable. The biomedical implant (16, 18) may be post treated to control the mechanical properties and/or corrosion rate thereof said Mg single crystal (10) without changing the chemical composition thereof. A method of making a Mg single crystal (10) for biomedical applications includes filling a single crucible (12) with more than one chamber with polycrystalline Mg, melting at least a portion of said polycrystalline Mg, and forming more than one Mg single crystal (10) using directional solidification.

The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.

A ceramic particle includes a core and a modification layer. The core is made of magnesium or a magnesium alloy. The core has a diameter of 30-100 μm. The modification layer covers an outer surface of the core. The modification layer includes calcium and phosphorus. A method for producing a ceramic particle includes providing a core made of magnesium or a magnesium alloy and having a diameter of 30-100 μm. A calcium salt and a phosphorus salt are dissolved in a solvent. A chelating agent is added into the solvent to form a modifying solution. The core is added into the modifying solution to form a modification layer on an outer surface of the core in a temperature range of 5-40° C. The modification layer includes calcium and phosphorus.