A matrix for neuron regeneration. The matrix can include a sheet having a first surface and a second surface opposite the first surface, the second surface having a plurality of integrally formed ridges. The sheet can have a spiral shape, such that the first surface of the sheet faces the second surface of the sheet. The sheet and the integrally formed ridges can comprise oligo(poly(ethylene glycol) fumarate).

Provided herein are devices and methods for treating inflammation and pain of articular joints (e.g., the knee). An implantable device includes an elongate body extending from a proximal end to a distal end, a flange disposed at the proximal end, a bore extending from an opening at the proximal end into the elongate body, one or more fixation members disposed on an outer surface of the elongate body, and a payload (e.g., a drug-polymer core) having a therapeutic agent disposed within the bore. The payload has a substantially constant surface area on an exposed portion throughout elution of the therapeutic agent after the implantable device is implanted in a body. The therapeutic agent is configured to elute using zero-order kinetics, constantly and continuously at an amount that is above a predetermined lower threshold and does not exceed a predetermined upper threshold unlike a pulse-dose injection.

Provided herein are devices and methods for treating inflammation and pain of articular joints (e.g., the knee). An implantable device includes an elongate body extending from a proximal end to a distal end, a flange disposed at the proximal end, a bore extending from an opening at the proximal end into the elongate body, one or more fixation members disposed on an outer surface of the elongate body, and a payload (e.g., a drug-polymer core) having a therapeutic agent disposed within the bore. The payload has a substantially constant surface area on an exposed portion throughout elution of the therapeutic agent after the implantable device is implanted in a body. The therapeutic agent is configured to elute using zero-order kinetics, constantly and continuously at an amount that is above a predetermined lower threshold and does not exceed a predetermined upper threshold unlike a pulse-dose injection.

An orthopedic implant having a subsurface level ceramic layer generally includes a base material, an intermix layer molecularly integrated with the base material that includes a mixture of the base material and a plurality of subsurface level ceramic-based molecules implanted into the base material, and an integrated ceramic surface layer molecularly integrated with and extending from the intermix layer forming at least part of a molecular structure of an outer surface of the orthopedic implant. The integrated ceramic surface layer and the base material thereafter cooperate to sandwich the intermix layer in between.

Provided is a dual light-responsive zinc oxide, in the preparation process of zinc oxide, sodium citrate and hydroxypropyl methyl cellulose are added to control the morphology, photothermal conversion materials are added to make zinc oxide have photothermal conversion ability, and lignin is added to reduce the energy band gap of zinc oxide; and the hydrothermal products after lyophilization are carbonized by microwave irradiation so as to further reduce the energy band gap. The dual light-responsive zinc oxide has a Tremella-like fold structure, has dual response to yellow light and near-infrared light, has excellent adsorbability, antibacterial property and photothermal stability, and has photothermal conversion ability. The dual light-responsive zinc oxide coating has both antibacterial and osteogenic properties, which can efficiently improve the antibacterial and osteogenic capability of implants when being applied on the surface of the implants; and its special photosensitive property helps to realize the photocontrol working and on-demand action of the antibacterial and osteogenic functions of the implant.

Provided is a dual light-responsive zinc oxide, in the preparation process of zinc oxide, sodium citrate and hydroxypropyl methyl cellulose are added to control the morphology, photothermal conversion materials are added to make zinc oxide have photothermal conversion ability, and lignin is added to reduce the energy band gap of zinc oxide; and the hydrothermal products after lyophilization are carbonized by microwave irradiation so as to further reduce the energy band gap. The dual light-responsive zinc oxide has a Tremella-like fold structure, has dual response to yellow light and near-infrared light, has excellent adsorbability, antibacterial property and photothermal stability, and has photothermal conversion ability. The dual light-responsive zinc oxide coating has both antibacterial and osteogenic properties, which can efficiently improve the antibacterial and osteogenic capability of implants when being applied on the surface of the implants; and its special photosensitive property helps to realize the photocontrol working and on-demand action of the antibacterial and osteogenic functions of the implant.

An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.

Methods for enhancing or accelerating osseointegration of an implant into bone marrow of a subject, the methods comprising increasing expression of peripheral clock neuronal PAS domain protein 2 (NPAS2) in the bone marrow, are provided. Expression of NPAS2 is increased by administration of a Npas2 modulating compound to the subject.

Methods for enhancing or accelerating osseointegration of an implant into bone marrow of a subject, the methods comprising increasing expression of peripheral clock neuronal PAS domain protein 2 (NPAS2) in the bone marrow, are provided. Expression of NPAS2 is increased by administration of a Npas2 modulating compound to the subject.