The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional neural tissues for use in methods including regenerative medicine, wound repair and transplantation.

Disclosed is a granule made of biocompatible metallic material, in particular made of titanium or titanium alloys, for vertebroplasty operations. The granule has a spherical shape and includes a central core with a solid structure, also spherical, having an outer surface from which a first diametrical rib and a second diametrical rib also having a solid structure, protrude. The ribs are advantageously arranged according to two diameters orthogonal to each other. The granule also includes a portion having a trabeculated structure which extends between the outer surface of the central core and the outer surface of the granule itself.

Disclosed is a granule made of biocompatible metallic material, in particular made of titanium or titanium alloys, for vertebroplasty operations. The granule has a spherical shape and includes a central core with a solid structure, also spherical, having an outer surface from which a first diametrical rib and a second diametrical rib also having a solid structure, protrude. The ribs are advantageously arranged according to two diameters orthogonal to each other. The granule also includes a portion having a trabeculated structure which extends between the outer surface of the central core and the outer surface of the granule itself.

The present invention provides customized hybrid bone-implant grafts and a method of manufacture thereof.

The present invention provides customized hybrid bone-implant grafts and a method of manufacture thereof.

The present invention provides novel multi-functional (e.g., repelling biofilms, promoting formation of minerals, and having anti-infection properties) biocomposites and methods of use thereof. In various embodiments, the present invention also provides method for simultaneously treating biofilms, promoting mineralization, treating infection, or any combination thereof.

The present invention provides novel multi-functional (e.g., repelling biofilms, promoting formation of minerals, and having anti-infection properties) biocomposites and methods of use thereof. In various embodiments, the present invention also provides method for simultaneously treating biofilms, promoting mineralization, treating infection, or any combination thereof.

There is provided a method of forming a structure that is in contact with an object, the method comprising: (i) supporting a flowable precursor with a flowable support at a position that allows said flowable precursor to be in contact with the object; and (ii) crosslinking at least part of the flowable precursor that is in contact with the object to form a structure that is in contact with the object, wherein a top surface of the part of the flowable precursor that is to be crosslinked, is in interface with a fluid medium. Also provided is a system for performing the method.

There is provided a method of forming a structure that is in contact with an object, the method comprising: (i) supporting a flowable precursor with a flowable support at a position that allows said flowable precursor to be in contact with the object; and (ii) crosslinking at least part of the flowable precursor that is in contact with the object to form a structure that is in contact with the object, wherein a top surface of the part of the flowable precursor that is to be crosslinked, is in interface with a fluid medium. Also provided is a system for performing the method.

Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.