The present invention generally relates to the use of pre-formed bodies of Chemically Bonded Ceramics (CBCs) biomaterial for implantation purposes wherein the bodies are prepared ex vivo allowing process parameters to be optimized for desired long term properties of the resulting CBC biomaterial. More particularly, the pre-formed CBC material bodies of the present invention are sintered. The pre-formed body of CBC material is machined to the desired geometry and then implanted using a CBC cementation paste for fixation of the body to tissue. The invention also relates to a method of preparing pre-formed bodies of CBC biomaterial for implantation purposes, methods of preparing an implant thereof having desired geometry, and a method of implantation of the implant, as well as a kit for use in the method of implantation.

The invention relates to a sternum replacement implant.

A prosthetic joint (100) comprises a first component (110) having a first interface portion (111). The prosthetic joint (100) further comprises a second component (120) having a second interface portion (121) with a textured surface (122) to interface with the first interface portion (111) and form a skeletal joint. The textured surface (122) can include a plurality of concave features (123). Each or the concave features (123) can be configured to compress a lubricant (140) to facilitate hydrodynamic lubrication between the first and second interface portions (111, 121) to minimize wear between the first interface portion (111) and the second interface portion (121) of the prosthetic joint (100).

The present invention relates to a method of fabricating an improved lithium silicate glass ceramic and to that material for the manufacture of blocks for dental appliances using a CAD/CAM process and hot pressing system. The lithium silicate material has a chemical composition that is different from those reported in the prior art with 1 to 10% of germanium dioxide in final composition. The softening points are close to the crystallization final temperature of 800 C. indicating that the samples will support the temperature process without shape deformation.

Various implementations of implants and implant surfaces for clinical rehabilitation or enhancement of a patient, related systems, and computer programs and methods for the design and manufacturing of implants are disclosed. A macroscale shape, a microscale surface texture, and a nanoscale surface topography are overlaid to increase, condition, and thereby functionalize an implant surface. A thin-film coating and/or laser interferometry is utilized to overlay on a machined implant substrate a nanoscale surface topography. Manufacturing the macroscale shape and the microscale texture may be performed with an ultrashort pulsed laser system in separate process steps. The design of a dental implant may be assisted by a self-learning computer program product, based on trained coupled shape models including, for example, mesh-based statistical shape and orientation models.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

To provide a sliding member having improved wear resistance, and a method of manufacturing the sliding member. A femoral head ball according to an aspect of the present disclosure includes a composite ceramic containing alumina and at least one oxide other than alumina. A surface roughness Ra of the sliding surface when the femoral head ball slides against a constituent member constituting an artificial joint is not more than 0.01 m. The sliding surface includes a plurality of recessed portions each having an opening diameter of not more than 2 m.

A fluoride treated medical implant, such as a dental component, is provided, the medical implant comprising fluorinated metal oxide on the substrate surface. A method for the preparation of such treated implants is also provided, the method involving exposure of the medical implant to a fluorine-containing reagent. A dental structure is also provided, which includes a first dental component comprising a fluorinated metal oxide layer on its surface, a silane coupling agent, a dental cement, and a second dental component having a surface bonded to the dental cement. An additional dental structure, which includes a first dental component comprising a fluorinated metal oxide layer on its surface, a dental cement, and a second dental component having a surface bonded to the dental cement is also provided.

Apparatus and methods for joint and bony segment replacement may utilize additive manufacturing (e.g., 3D printing) of various anatomic constructs with PEEK/zeolite/ion (PZI) material. Heavy metal ion loading options may be utilized which may provide differing properties to different surfaces of the resultant apparatus. Moreover, using the PZI material, the apparatus being implanted in joint and bony segment replacement may favorably manipulate the biologic microenvironment in which it may be implanted. Further, through use of PZI material, current large joint replacement options also may be disrupted including, but not limited to, modifications of the joint replacement itself, and the augments and supporting joint reconstruction devices used in bone loss situations. Methods for joint and bony segment replacement may provide mixing two or more types of PZI material together through an additive manufacturing process; and introducing the mixture as part of an implantable apparatus.

To provide a sliding member having improved wear resistance, and a method of manufacturing the sliding member. A femoral head ball according to an aspect of the present disclosure includes a composite ceramic containing alumina and at least one oxide other than alumina. A surface roughness Ra of the sliding surface when the femoral head ball slides against a constituent member constituting an artificial joint is not more than 0.01 m. The sliding surface includes a plurality of recessed portions each having an opening diameter of not more than 2 m.