The present disclosure relates to a biocompatible, electrically conductive membrane capable of carrying the electrical potential of a cardiac impulse. The present disclosure also relates to treatments using the electrically conductive polymer, such as for atrial fibrillation.

A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.

The present disclosure provides click-crosslinked hydrogels and methods of use.

An object of the present invention is to provide a method for producing a sheet-like cell structure having excellent strength and shape-maintaining performance, and a sheet-like cell structure having excellent strength and shape-maintaining performance. According to the present invention, there is provided a method for producing a sheet-like cell structure, including: a step of adding a biocompatible macromolecular block, a cell, and a liquid medium onto a culture support body having a plurality of recessed portions on a culture surface, and immersing the biocompatible macromolecular block and the cell in uppermost portions of the recessed portions; and a step of culturing the cell to obtain a sheet-like cell structure.

The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.

Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.

Moisture diverters attachable to a region above the eye and below the eyebrow that prevents sweat, liquid, moisture, or the like from entering the eyes of a wearer is described. A moisture diverter may include a substrate having an inner surface facing the wearer and an outer surface facing away from the wearer. The inner surface comprises a lower adhesive section and an upper adhesive-free section, the adhesive section releasably attaches the diverter to the wearer at a point above the eye and below the eyebrow, the adhesive-free section shaped or shapeable to abut or protrude from eyebrow region of a wearer and to divert moisture away from the eye.

A hydrogel comprising: water; an alginate; a glucono-delta-lactone (GDL); and microparticles comprising an inorganic calcium compound and recombinant gelatin. The hydrogels may be used for bone repair and/or regeneration.

The present disclosure relates generally to biomaterial implants and methods for delivering a cell to an individual in need thereof and, more particularly, to biomaterial implants and techniques for delivering islets and/or β-cell progenitors to an individual.

An oxygen-releasing biomaterial, articles and methods, and more particularly an oxygen-releasing biomaterial with sustained oxygen-releasing properties of four to five weeks, which is suitable for tissue engineering scaffolds, is disclosed. The biomaterial contains a hydrogel with a plurality of microparticles suspended in the hydrogel. The microparticles contain an oxygen carrier that is encapsulated in a biocompatible hydrophobic material, where the release of oxygen from the oxygen carrier is sustained over a four to five week period. The biomaterial has application in tissue engineering, osteogenesis, burn and wound treatment, and treatment of cardiac conditions, and has further antimicrobial properties.