Biomimetic scaffolds for neural tissue growth are disclosed herein which have a plurality of microchannels disposed within a sheath. Each microchannel comprises a porous wall that is formed from a biocompatible and biodegradable material. The biocompatible and biodegradable material may be polyethylene glycol) diacrylate, methacrylated gelatin, methacrylated collagen, or polycaprolactone, and combinations thereof. The biomimetic scaffolds have high open volume % enabling superior (linear and high fidelity) neural tissue growth, while minimizing inflammation near the site of implantation in vivo.

The present invention features a neural organoid that recapitulates in vitro most characteristics of the brain (e.g., human), and methods of using this neural organoid to study disease and to identify therapeutic agents for the treatment of neurological diseases and disorders.

Expanded, nanofiber structures comprising electrospun nanofibers, a plurality of holes, and, optionally, cells are provided. Methods of making the nanofiber structures as well as methods of use thereof, particularly for wound healing, are also provided.

In one embodiment, the present invention provides a composition, wherein the composition is a porous scaffold, wherein the pores of the scaffold are from 1 to 500 microns, the composition comprising: a) a cross-linkable protein selected from the group consisting of collagen and gelatin; b) a cross-linker which induces cross-linking of the cross-linkable protein; and c) a liquid.

In one embodiment, the present invention provides a composition, wherein the composition is a porous scaffold, wherein the pores of the scaffold are from 1 to 500 microns, the composition comprising: a) a cross-linkable protein selected from the group consisting of collagen and gelatin; b) a cross-linker which induces cross-linking of the cross-linkable protein; and c) a liquid.

In a method for implantation of a physically stabilized aggregate of living cells or tissue fragment is injected into a channel provided in soft tissue filled with an aqueous gel. Also discloses are methods of stabilizing such aggregates and fragments and of forming such channel in soft tissue as well as means for carrying out the methods.

Three-dimensional printed antibiotic scaffolds are provided as well as methods of use thereof and methods of making.

Coated and expanded, nanofiber structures are provided and methods of use thereof.

The present invention relates to a process for the surface treatment of poly(aryl ether ketone)s (PAEKs) comprising the following steps: Providing an article comprising one or more poly(aryl ether ketone)s (PAEKs); contacting at least one portion of the surface of the article containing one or more poly(aryl ether ketone)s (PAEKs) with an aldehyde,
wherein the aldehyde reacts with the poly(aryl ether ketone)(s) (PAEKs) on the at least one portion of the surface of the article to form a hydroxyalkyl and/or hydroxyaryl group,
a process for functionalizing surface-treated poly(aryl ether ketone)s (PAEKs) comprising the steps of: a) Treating at least one portion of the surface of an article containing one or more poly(aryl ether ketone)s (PAEKs) with the surface treatment process for poly(aryl ether ketone)s (PAEKs) described herein; b) Coating the treated at least one portion of the surface of the article with a composition comprising a chemical compound having chemical groups capable of forming a covalent bond with hydroxyalkyl and/or hydroxyaryl groups formed on the surface of the article,
an article comprising one or more poly(aryl ether ketone)s (PAEKs) and a coating on at least one surface of the article, wherein on the coated at least one portion of the surface of the article the poly(aryl ether ketone)(s) (PAEKs) contains hydroxyalkyl and/or hydroxyaryl groups; and at least one portion of the hydroxyalkyl and/or hydroxyaryl groups of the poly(aryl ether ketone)(s) (PAEKs) has formed covalent bonds with chemical groups of at least one chemical compound in the coating, and
the use of the article of the invention as described herein as a medical device and/or biotechnological applications, preferably as an implant, scaffold structure for in vitro applications and/or scaffold structure for cell culture applications.

A nerve regeneration-inducing tube includes a cylindrical body, and a plurality of fibers that are housed in the body and extend in a longitudinal direction of the body. At least a part of the fibers is a modified cross-section fiber that has an axis extending in a longitudinal direction of the fibers, and at least three protrusions that continue in the longitudinal direction of the fibers, protrude from the axis, and have a height of 0.5 μm or more from the axis.