A three-dimensional hydrogel scaffold of the present invention contains a cell to be transplanted in vivo and comprises a first hydrogel block on which a plurality of holes are formed and one or more second hydrogel blocks which are assembled to the holes and are biodegradable. A large hydrogel scaffold can be prepared by means of the assembly of the blocks. The survivability of the cell being transplanted is high and the biodegradability of the blocks varies, and thus the risk of hypoxia is reduced.

A three-dimensional hydrogel scaffold of the present invention contains a cell to be transplanted in vivo and comprises a first hydrogel block on which a plurality of holes are formed and one or more second hydrogel blocks which are assembled to the holes and are biodegradable. A large hydrogel scaffold can be prepared by means of the assembly of the blocks. The survivability of the cell being transplanted is high and the biodegradability of the blocks varies, and thus the risk of hypoxia is reduced.

The present invention relates to a hydrogel composition for tissue regeneration, and a support prepared using same. More specifically, the present invention comprises anionic polysaccharides, aminated hyaluronic acid, and collagen. The hydrogel composition comprising the ingredients, and a support prepared using same can quickly form a three-dimensional structure through spontaneous cross-linking without the addition of a common cross-linking agent in which an epoxide group or an amine group is at a single end or both ends thereof, thereby providing a structure capable of soft tissue transplants.

The present invention relates to a hydrogel composition for tissue regeneration, and a support prepared using same. More specifically, the present invention comprises anionic polysaccharides, aminated hyaluronic acid, and collagen. The hydrogel composition comprising the ingredients, and a support prepared using same can quickly form a three-dimensional structure through spontaneous cross-linking without the addition of a common cross-linking agent in which an epoxide group or an amine group is at a single end or both ends thereof, thereby providing a structure capable of soft tissue transplants.

A tissue engineering material for nerve injury repair, a preparation method therefor and an application thereof. The tissue engineering material for nerve injury repair is an N-cadherin crosslinked linear ordered collagen scaffold. By crosslinking N-cadherin with a linear ordered collagen scaffold, the prepared tissue engineering material can efficiently induce migration of neural stem cells towards an injury region so that the neural stem cells are enriched in the injury region, and can effectively inhibit deposition of inhibitory factors such as chondroitin sulfate proteoglycan, promote differentiation of the neural stem cells into neurons, and then promote recovery of electrophysiological and motion functions. The N-cadherin crosslinked linear ordered collagen scaffold also has a stable ordered topological structure and excellent mechanical properties, and can be used to repair nerve injuries such as spinal cord injury.

A tissue engineering material for nerve injury repair, a preparation method therefor and an application thereof. The tissue engineering material for nerve injury repair is an N-cadherin crosslinked linear ordered collagen scaffold. By crosslinking N-cadherin with a linear ordered collagen scaffold, the prepared tissue engineering material can efficiently induce migration of neural stem cells towards an injury region so that the neural stem cells are enriched in the injury region, and can effectively inhibit deposition of inhibitory factors such as chondroitin sulfate proteoglycan, promote differentiation of the neural stem cells into neurons, and then promote recovery of electrophysiological and motion functions. The N-cadherin crosslinked linear ordered collagen scaffold also has a stable ordered topological structure and excellent mechanical properties, and can be used to repair nerve injuries such as spinal cord injury.

The invention relates to engineered collagen scaffolds with a thickness of from about 0.005 mm to about 3 mm, and with a high strength (e.g., a high elastic modulus of from about 0.5 MPa to about 200 MPa). The engineered collagen scaffolds can be non-collapsible and/or non-expandable. This disclosure also relates to methods of use of these collagen scaffolds.

The invention relates to engineered collagen scaffolds with a thickness of from about 0.005 mm to about 3 mm, and with a high strength (e.g., a high elastic modulus of from about 0.5 MPa to about 200 MPa). The engineered collagen scaffolds can be non-collapsible and/or non-expandable. This disclosure also relates to methods of use of these collagen scaffolds.

The present disclosure relates to a three-dimensional, degradable medical implant for regeneration of soft tissue comprising a plurality of volume-building components and a mesh component which is substantially made of monofilament or multifilament fibers, wherein each volume-building component is attached to at least one point on a surface of the mesh component, and wherein the projected surface area of each volume-building component, when projected on the surface of the mesh component, corresponds to a maximum of one tenth of the surface area of the mesh component.

The present disclosure relates to a three-dimensional, degradable medical implant for regeneration of soft tissue comprising a plurality of volume-building components and a mesh component which is substantially made of monofilament or multifilament fibers, wherein each volume-building component is attached to at least one point on a surface of the mesh component, and wherein the projected surface area of each volume-building component, when projected on the surface of the mesh component, corresponds to a maximum of one tenth of the surface area of the mesh component.