The present invention relates to a dental implant that contains a metal-organic framework (MOF) structure involving antibacterial metal ions, especially silver (Ag), thus can release long-term and controlled antibacterial metal ions and exhibits a long-term antibacterial/antimicrobial effect, has osseointegration capability and high biocompatibility and a method for preparing this dental implant.

To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 10% to 90% is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film to suppress adhesion of bacteria.

An implantable device for mounting to a patient's bone includes a housing and at least one osseointegrating protuberance. The housing includes a surface having an abutting portion configured to abut the bone when the housing is implanted in the patient, the abutting portion defining a housing axis orthogonal to the surface. The at least one osseointegrating protuberance: extends from the surface of the housing; is adapted to abut the patient's bone; and has a substantially smooth shaft.

A method forms an implant with a base body made of a biocorrodible magnesium alloy. The methods make magnesium alloy that contains a plurality of statistically distributed particles, with one or more of the elements Y, Zr, Mn, Sc, Fe, Ni, Co, W, Pt and noble earths with the atomic numbers 57 to 71, or the particles comprise alloys or compounds containing one or more of the elements mentioned. The mean distance of the particles from each other is smaller than the hundredfold mean particle diameter.

Disclosed is a medical device having a substrate having an exposed surface and a texture over at least part of the exposed surface. The texture includes a plurality of nanofeatures that inhibit bacterial adhesion on the surface and that also inhibit bacterial growth on the surface and have a size range between about 0.01 nanometers and about 1,000 nanometers. The texture can include a plurality of nanofeatures applied thereto such that the texture has a first particle size at a first location, a second particle size at a second location, and a gradient of particle size from the first particle size to the second particle size between the first location and the second location.

Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.

It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized. The magnetized devices are used to attract, capture, and/or retain magnetically labeled cells on the surface of the device in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe/Pt particle is very important for introducing a L10 interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e. starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a “Super Conducting Quantum Interference Device”, which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.

A coated powder composite may include a core particle of Ca or an alloy thereof, or of Mg or an alloy thereof. One or more coating layers may be disposed about the core particle, cladding the core particle. The coated powder composite may be biodegradable.

The present invention provides Dental implant configured to be inserted into a hole in jaw bone and to be at least partially situated in bone tissue when implanted, comprising: a coronal implant region, the surface of which is at least partly covered by an oxide layer with an average thickness in the range from 60 nm to 170 nm and has an average arithmetical mean height Sa in the range from 0.1 μm to 1.0 μm. Further provided is a component for dental applications, preferably dental abutment, wherein the surface of the component is at least partly covered by an oxide layer with an average thickness in the range from 60 nm to 170 nm and has an average arithmetical mean height Sa in the range from 0.05 μm to 0.5 μm and an implant system comprising the dental implant and the component. Method for forming a protective layer on the surface of an implantable or implant component, the method comprising a) applying a solution on the surface of component, the solution having a pH at 25° C. of 6.8 or less and b) drying the solution applied in step a) to form a protective layer on the surface of the component for dental applications. Finally, part of the present invention is an implantable or implant component having a protective layer obtainable as above and a use of such layer for storage.

The present invention relates to a magnesium alloy material, which is an in situ magnesium hydroxide nanosheet layer modified magnesium alloy. The material is prepared from a magnesium alloy through a hydrothermal reaction under alkaline condition. The protective effect of the in situ formed magnesium hydroxide nanosheet layer structure results in remarkably enhanced corrosion resistance of the magnesium alloy, meanwhile the biocompatibility can also be significantly improved since the release rate of magnesium ion can be significantly reduced. In addition, the two-dimensional nanolayer structure has a non-releasing physical antibacterial property depending on contact. Therefore, the magnesium alloy material according to the present invention has an extremely great application prospect in the field of medical implant.