A dental implant made of a material comprising titanium. The implant includes a head portion having a non-rotational feature, a lowermost end opposing the head portion, and a threaded bottom portion for engaging bone between the head portion implant and the lowermost end. The implant further includes a nanocrystalline surface formed on at least a portion of the implant. The nanocrystalline surface includes discrete nanocrystals deposited on a roughened surface of the implant. The roughened surface includes at least one of a grit-blasted surface or an acid-etched surface. A portion of the roughened surface is exposed between at least some of the discrete nanocrystals such that the exposed roughened portion between the discrete nanocrystals is capable of contacting bone.

A dental implant made of a material comprising titanium. The implant includes a head portion having a non-rotational feature, a lowermost end opposing the head portion, and a threaded bottom portion for engaging bone between the head portion implant and the lowermost end. The implant further includes a nanocrystalline surface formed on at least a portion of the implant. The nanocrystalline surface includes discrete nanocrystals deposited on a roughened surface of the implant. The roughened surface includes at least one of a grit-blasted surface or an acid-etched surface. A portion of the roughened surface is exposed between at least some of the discrete nanocrystals such that the exposed roughened portion between the discrete nanocrystals is capable of contacting bone.

The invention relates to a knee joint prosthesis comprising a femoral component (1) and a tibial component (2), each having a front face constituting the joint and a rear face (4) facing the bone, and a polyethylene (PE) liner (3). In order to allow the knee joint prosthesis to be implanted without metal and without cement, the femoral component (1) and the tibial component (2) consist of a full ceramic material and both components (1, 2) have integrated porous osseointegrative rear faces (4) facing the bone.

The invention relates to a knee joint prosthesis comprising a femoral component (1) and a tibial component (2), each having a front face constituting the joint and a rear face (4) facing the bone, and a polyethylene (PE) liner (3). In order to allow the knee joint prosthesis to be implanted without metal and without cement, the femoral component (1) and the tibial component (2) consist of a full ceramic material and both components (1, 2) have integrated porous osseointegrative rear faces (4) facing the bone.

A method of coating a medical implant with hydroxyapatite comprises steps of: (a) plasma treating said medical implant by a plasma electrolytic oxidation bath within an electrolyte; (b) hydroxyapatite coating a plasma treated medical implant in a hydrothermal pressurized reactor; (c) washing a hydroxyapatite coated medical implant; and (d) drying a washed medical implant. At least one of steps a and b further comprises a sub-step of forming crystallization seeds on a surface of said medical implant.

A method of coating a medical implant with hydroxyapatite comprises steps of: (a) plasma treating said medical implant by a plasma electrolytic oxidation bath within an electrolyte; (b) hydroxyapatite coating a plasma treated medical implant in a hydrothermal pressurized reactor; (c) washing a hydroxyapatite coated medical implant; and (d) drying a washed medical implant. At least one of steps a and b further comprises a sub-step of forming crystallization seeds on a surface of said medical implant.

An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

Methods are provided for modifying a porous surface of an implantable medical device by subjecting the porous surface to a modified micro-arc oxidation process to improve the ability of the medical device to resist microbial growth, to improve the ability of the medical device to adsorb a bioactive agent or a therapeutic agent, and to improve tissue in-growth and tissue on-growth of the implantable medical device.

This disclosure relates to methods of mineralizing cell-laden matrices. Disclosed herein are cell-laden matrix compositions. Also disclosed herein are methods of selectively mineralizing a cell-laden matrix. Methods of culturing biomimetic bone tissue are disclosed herein. Also disclosed herein are kits containing compositions disclosed herein or portions thereof.