Systems, methods, and devices include techniques for generating and using a demineralized bone matrix (DBM)-gelatin matrix allograft material. The DBM-gelatin material can be used to form an implant (e.g., for sternal closure operations) and/or a gel (e.g., for wound/fracture treatment). A method for forming the implant or bone graft can include forming the DBM from an initial bone material; and mixing, in a solution, the DBM with a gelatin carrier to form a DBM-gelatin solution. The gelatin carrier can include an animal-based collagen, such as a porcine-based collagen or a bovine-based collagen. Additionally, the method of forming the bone graft can include performing a crosslinking reaction with the DBM-gelatin solution. The implant can be packaged in a sterile hydration container prior to use.

The present disclosure relates to novel bone putty compositions comprising a silicate-containing preparation and bone and/or a bone surrogate material, and methods for making and using the same in healing damaged bone in a subject in need thereof. The present compositions may also promote healing of soft tissue contiguous with the treated damaged bone which is in contact with the present compositions. In some embodiments, the present compositions are stabilized, and contain silicate-containing particles having a mean diameter of from about 1 to about 20 nm. Such particles may impart unique healing characteristics to the composition, both with respect to the damaged bone and the surrounding soft tissue. The present compositions and methods may find particular utility in the oral cavity of the subject.

Provided is an implantable composite which includes a plurality of resorbable ceramic particles with or without a biodegradable polymer. The resorbable ceramic particles can be granules including carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. Some resorbable ceramic particles are granules, which include carbonated hydroxyapatite and β tricalcium phosphate in a ratio of 5:95 to 70:30. The resorbable ceramic particles have a particle size from about 0.4 to about 3.5 mm. The implantable composite is configured to fit at or near a bone defect as an autograft extender to promote bone growth. Methods of using the implantable composite are also provided.

A bone pore or void filling composition is described. The composition includes a mixture of: a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate; a blend of polyethylene glycol polymers having different molecular weights; a bone growth stimulator; and bioactive glass. A kit for containing the bone pore or void filling composition, and methods for using the composition to fill a bone pore or void are also described.

The present invention provides a method for preparing a bone protein preparation which contains for example growth factors. The present invention also provides a bone protein preparation obtained by the method and paste, putty, pellet, disc, block, granule, osteogenic device or pharmaceutical composition containing said bone protein preparation.

A filter device comprises a frame with interrupted perimeter having a top surface and a bottom surface and a screen having a plurality of pores is attached to the frame. The filter device designed to fit into an interior of a container. The container is configured to contain a mixture of Demineralised Bone Matrix (DBM) containing bone graft material and liquid. The liquid mixture can be poured out of the container through the pores in the screen on the filter device and separated from the bone graft material while the DBM containing the bone graft material remains in the container. The pores are sized smaller than DBM particles to prevent the DBM particles from separated from the bone graft material with the liquid.

A delivery system comprising an agent and a foldable covering including a first surface disposed with the agent and a second surface connectable with the first surface to intra-operatively dispose the covering in a selected configuration.

A bone graft composition comprising a viable, osteogenic cellular material combined with a viscous cryoprotectant that includes a penetrating cryoprotective agent and a non-penetrating cryoprotective agent. The viscosity of the cryoprotectant is such that the composition is malleable, cohesive and capable of being formed into desired shapes.

The present invention relates an ion substituted bovine-derived hydroxyapatite (ion substituted BHA) with at least one type of ion selected from F, Si, Cl, carbonate, citrate, Na, K, Ag, Mn, Zn, Zr, Cu, Co, Fe, Au, B, Ba, Al, Bi, Mg or Sr, or combinations thereof. The modified BHA by ionic doping augments the strength and biocompatibility of the bone graft, reduces healing time, and have a minimal reaction in the body after surgery. The various aspects of the ion-substituted BHA of the present invention have been described along with the FIGS. 1 to 50. The present invention also relates to a process of preparing the ion substituted bovine-derived hydroxyapatite. The invention further relates to a scaffold comprising the ion-substituted bovine-derived hydroxyapatite.

The present invention relates to a method for sterilizing a bone graft material, and more specifically, to a method for sterilizing a bone graft material containing sodium carboxymethyl cellulose (CMC) gel without changing its properties.