Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.

A method of making a bone matrix includes exposing a bone tissue to a solution including a surfactant and a protease; treating the bone tissue with an acid solution following exposing the bone tissue; and electrophoretically treating the acid treated bone tissue. A bone matrix has a DNA content of not greater than 0.1 micrograms per milligram sample and a modulus in a range of 180 kPa to 250 kPa.

An implant that can hold bone graft material, and receive support from adjacent tissues and structures. In one aspect, the implant has an attachment region to directly engage with adjacent tissues and structures. In another aspect, the implant is malleable and can be manipulated to conform to the adjacent tissues and structures.

The present disclosure relates to a bone graft composition, and more particularly, to a bone graft composition including: a bone graft material; a thickener having an adhesive property; and hydroxypropyl methylcellulose as a crosslinker that forms a bond with each of the bone graft material and the thickener.

Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may include demineralized cortical fibers, which help to promote bone repair.

A method of making a bone graft composition is described wherein material including decalcified bone elongated particulate bone is dried in a constraining device or under pressure to produce a solid construct having dimensions corresponding to the constraining device or space to which the material occupied under pressure.

The present invention provides a method for preparing a bone protein preparation which contains for example growth factors. The present invention also provides a bone protein preparation obtained by the method and paste, putty, pellet, disc, block, granule, osteogenic device or pharmaceutical composition containing said bone protein preparation.

A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

An intervertebral implant comprising a body formed as an open truss structure, the body having a generally annular shape with a superior surface, an inferior surface, and a perimeter surface extending around an outer periphery of the body. The body may have a central portion and a peripheral portion, the peripheral portion extending inward from the perimeter surface toward the central portion, the peripheral portion including a first set of trusses, and the central portion including a second set of trusses. The implant may further include a strut at least partially defining a boundary between the central portion and the peripheral portion, wherein the strut has an oblong cross-sectional shape oriented to facilitate flow of bone graft material in a substantially radial direction away from the central axis.

Apparatus for producing strips of bone fibre comprising a vice for securing a section of rigid bone with which said apparatus is used, said vice defining a containment area and having a compression axis with which a longitudinal axis of said bone is substantially aligned in use, an arm for reciprocal linear movement along a movement axis between a rearward position and a forward position, said movement axis being parallel with said compression axis and spaced therefrom in a lateral plane, a first drive mechanism for moving said arm along said movement axis in a reciprocal manner, and a cutting head comprising a first row of cutting teeth, which cutting head is mounted to a first end of said arm with said first row of cutting teeth coincident with said containment area and disecting said lateral plane, and a method of producing a DBM fibres product using such apparatus.