Method of the osteoreparative processes' correction and/or bone defect restoration by means of human cell-based products (cell and/or tissue transplants) and the method of its manufacturing. The invention a creates and establishes conditions for osteoreparative processes restoration in destroyed bone tissue by osteoreparation cell sources restoration as the result of use cell technologies and bone tissue engineering methods, e.g. scaffold-guided regeneration, particularly by means of cell transplantation by injection and/or transplantation of original three-dimensional osteoreparative prevascularized graft (3D-OPG). Manufacturing of medical products and preparations of the product based on human cells (cell and/or tissue transplants) is dedicated for impaired osteoreparative processes correction and/or bone defect restoration.

The present invention relates to methods for producing biphasic calcium phosphate materials using chemical processing methods including exposure to peroxides. The resulting materials exhibit an osteoinductive needle-like surface morphology and are useful as artificial bone grafts.

The present invention provides for a removable second stage biocompatible substrate filter that includes biocompatible implant material configured to trap second stage operative particulate matter that may include at least one of bone fragments, plasma, stem cells, cellular matter, and growth factors captured from irrigation fluid. The second stage biocompatible substrate filter may be configured to combine with bone fragments captured from irrigation fluid by a first stage filter and may be configured to be operable with a reaming and collection device.

Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

A new composition has been developed that incorporates S1P into a conventional demineralized bone matrix material. Once the device is implanted into the spine, the S1P will elute out of the device, thereby setting up a concentration gradient in the vicinity of the device. This gradient will cause stem cells to preferentially migrate to the device.

Provided are methods and compositions for maxillofacial and/or periodontal bone repair in hyperglycemic and/or diabetic subjects.

The present invention provides customized hybrid bone-implant grafts and a method of manufacture thereof.

Demineralized bone matrix (DBM) compositions, methods of making and methods of treatment with the same are provided. The DBM compositions are made from mechanically entangled bone material that does not contain a carrier. The coherent mass of mechanically entangled demineralized bone fibers can be obtained by needle punching with barbed needles, entanglement with water or air jets, or by applying ultrasonic waves to the demineralized bone fibers. A coherent mass of mechanically entangled demineralized bone fibers can also be obtained by application to demineralized bone fibers of moisture, heat and pressure provided by pressure rollers. A method of making a bone material for hydration with a liquid is also provided. The method includes subjecting demineralized bone fibers to mechanical entanglement to obtain a coherent mass of demineralized bone fibers in the absence of a carrier. A method of treating a bone cavity with a mass of mechanically entangled demineralized bone fibers is also provided. The method of treatment includes implanting into a bone cavity a coherent mass of mechanically entangled demineralized bone fibers, wherein the coherent mass of mechanically entangled demineralized bone fibers does not contain a carrier.

Disclosed are various bioactive and/or biocompatible materials and methods of making the same.

Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such composite and uses thereof. The osteoconductive matrix can be a tricalcium phosphate, bioglass, or the like, and can include particles that are surface modified. Growth factors can be provided in powder form, including bone morphogenic proteins such as rhBMP-2. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells.