In some forms, the present disclosure provides systems and methods for isolation of platelet rich plasma from a liquid tissue sample. In accordance with some forms of the disclosed systems and methods, provide rapid separation of blood components with the need for centrifugation. Accordingly, in one embodiment, the present disclosure provides a method for isolating platelet rich plasma, the method comprising combining a liquid tissue sample with a polymer composition, the polymer composition comprising polyethylene glycol.

The disclosure herein includes uses and systems for cataract removal and lens regeneration using endogenous stem cells that results in improved outcomes.

Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.

Disclosed are phospholipid based compositions and implant devices, as well as methods and kits that include such compositions or components thereof. In particular, the present compositions include a polymer component such as a poloxamer or PEG component and a phospholipid component, such as a Phosal. The present compositions may include at least one additional component, such as granules, powder and/or particulates. The present compositions may further include one or more bone graft materials and/or active ingredients. The compositions may be used on their own or incorporated on or in a surgical implant.

The present invention is related to the field of tissue regeneration. It concerns more particularly new manufacturing machines and processes, new A-PRP or PRP, hyaluronic acid and/or chitosan compositions, used alone or in combination, and related devices.

An acellular product may be derived from human placenta and may be used in various scenarios for wound healing. Because the product may be acellular, the product may be processed for storage and transportation with minimal degradation. The product may include various scaffolding such as biomaterials or human tissue, and the scaffolding may be infused with various plasmas and agents. The cell-free treatment may maintain the biological activity of many therapeutic agents found within cells and may possess multiple structural components to support cellular attachment. The structural components or scaffolds may function as a reservoir of highly diffusible chemotactic and cellular-programming factors that may be useful to treat injury and disease.

A device for treating an artificial bone implant with blood, the device comprising: a container configured to accommodate an artificial bone implant and be filled with blood, wherein the container comprises an opening; and a cover configured to cover the opening of the container. Additional embodiments of the device and methods for using the same are disclosed herein.

The invention provides for a method of preparing an isolated serum fraction of platelet rich fibrin (PRF), comprising the steps of a. providing platelet rich plasma (PRP) without the addition of an anticoagulant; b. clotting the PRP to obtain a coagel of PRF; and c. separating the coagel to isolate the serum fraction which comprises an activated platelet releasate; and further provides for the isolated serum fraction obtained by such method, and its medical use.

Methods and compositions for repair and regeneration of neural tissue are provided. Particularly, methods and compositions for promoting neural tissue wound healing and treatment of traumatic brain injury using porous crystalline calcium carbonate particles and a biocompatible polymer, for example compositions comprising porous coral exoskeleton particles in combination with a biocompatible polymer, and optionally comprising neural growth agents and platelets for application to damaged neural tissue for enhancing neural regrowth and recovered functionality, in, for example, but not limited to, traumatic brain injury (TBI).

A mixing and delivery device for flowable, homogenous material compositions and methods of use are provided. A kit for use by a medical professional is also provided.