The present disclosure relates to a method for manufacturing particulate tissue products. The methods can include cutting a sheet of tissue matrix into elongated strips. In various embodiments, the method for manufacturing particulate tissue product further includes bundling the strips and slicing the bundle into particulate tissue product. The particulates may have improved properties, such as a uniform size distribution.

A uniformly hydrated composition is provided and methods of making the uniformly hydrated composition. The method comprises providing a plurality of lyophilized porous macroparticles in a chamber, the plurality of lyophilized porous macroparticles each having an average diameter from about 0.1 mm to about 10 mm and comprising ceramic material and polymer; and mixing each of the plurality of lyophilized porous macroparticles with a fluid in the chamber to uniformly hydrate each of the plurality of lyophilized porous macroparticles to form a uniformly hydrated composition. Hydratable compositions are also provided.

A temporary space-filling penile implant device for penile surgery includes a body portion, an end portion attached to the body portion, and a cover surrounding the end portion and at least a portion of the body portion. The temporary space-filling penile implant may be configured for insertion into either corpora cavernosa of a penis or into interior tissue of a neophallus, during an inter-procedure time period that occurs between two surgical procedures performed on the penis or the neophallus.

A method is provided comprising harvesting epidermal tissue at a resection site and forming a first substance including the epidermal tissue. The method includes harvesting dermal tissue at the resection site and forming a second substance including the dermal tissue. A skin graft is formed comprising the first substance and/or the second substance.

An acellular dermal matrix (ADM) graft product includes an ADM graft derived from full-thickness skin, with a pre-formed shape having a mesh pattern formed therein. The ADM graft is disposed in a sterilization package and irradiated to provide a two year shelf-life for the ADM graft product, which is used in the time-saving, efficient, and effective surgical reconstruction of soft tissue defects. One manufacturing method involves providing a portion of full-thickness donor-derived skin, removing an epidermis and a fat layer form the portion of the skin, decellularizing the portion of the skin to form a portion of ADM graft material, pre-shaping and meshing the ADM graft material, verifying a thickness of the ADM graft material, and packaging the pre-shaped, meshed ADM graft material in a sterilizable package and irradiating for a two-year shelf-life to form the ADM graft product. Other embodiments are also disclosed.

This disclosure is directed to methods for reconstructing an unstable triangular fibrocartilage complex (TFCC). Exemplary methods include preparing, delivering, and fixating a graft within a distal radioulnar joint in a manner that restores the functionality to the TFCC, thereby improving the joint kinematics of the radioulnar joint.

The invention is employing the application of tilapia skin that has been processed and preserved in a dried tissue stage. To reach dried tissue stage, the fish skin is required to undergo treatment of Gludehyde and Glycerin solutions that is performed inside the clean room. The skin in new dried stage is then integrated with an adhesive strip and sterile gauze inside the clean room to create a new type of Ready-To-Use bandage that can be utilized as medical dressing for skin injuries, namely Revi-Aid.

An implantable device for penile construction includes a tissue ingrowth cover. The tissue ingrowth cover may be disposed between a penile prosthesis and an interior wall of a neophallus, when the penile prosthesis is implanted within the neophallus.

A needle array guide for a skin graft expansion apparatus includes: a lower side having openings; and guide channels respectively leading to the openings and converging closer toward one another as the guide channels approach the openings, the guide channels configured to receive a plurality of hollow needles, arranged in a needle array and having respective tips to be attachable to minced skin particles obtained from a skin graft, to thereby guide movement of the plurality of hollow needles when the plurality of hollow needles are being protruded from the openings toward the minced skin particles and when the plurality of hollow needles are being retracted toward the openings. The needle array guide may be included as part of a skin graft expansion apparatus that further comprises the needle array. The skin graft expansion apparatus may be included as part of a skin grafting system.

A two-layer gradient coating article is provided that is operable to cause selective adhesion and directional migration of endothelial cells. The first layer includes cell-resisting polymers that repels cells, the second layer includes one layer of peptides that has affinity to and binds specifically to endothelial cells. Furthermore, the peptides are distributed in a gradient, in which attached ECs migrate towards the direction of increased concentration, thus enriching the ECs to a desired locus. The combination of a cell-repelling layer and a graded affinity peptide produces a unique result of selective adhesion, directional migration, thus local enrichment of endothelial cells. A method for using such gradient coating article and its potential use in treating cardiovascular diseases are also provided. The invention provides an inexpensive, stable and effective means for attracting ECs to desirable locations.