The claimed method for performing ophthalmosurgical operations includes forming a recipient bed and implanting an autograft consisting of a portion of the patient's own nail plate, which is shaped to fit the recipient bed, and which is sterilized and then kept in a dry environment prior to implantation. The autograft is similar in chemical composition and physical characteristics to the tissues of the eye, is not accompanied by an immune system rejection reaction, and adapts to the shape of the recipient bed as a result of natural swelling.

The present invention relates to a biomaterial-derived sheet-like decellularized material having a maximum value of tensile strength in four directions of 4 MPa or more and an elongation rate in the direction exhibiting the maximum tensile strength of 50% to 300%. The present invention can provide a sheet-like material capable of maintaining excellent pressure resistance when used as an artificial blood vessel or for repair of a blood vessel.

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

The present disclosure provides meshed acellular dermal tissue matrix compositions, devices, and methods of use. The meshed devices can be used in conjunction with a variety of implants such as breast implants or tissue expanders.

The present disclosure provides tissue fillers. The tissue fillers can include a plurality of tissue particles formed from acellular tissue matrix fragments. The tissue fillers can be used to fill tissue sites, such as voids formed after tissue resection.

The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.

Provided are compositions and methods for achieving time-delayed cross-linking of hyaluronic acid (HA) to be used as a soft tissue filler. The compositions may include at least one component that facilitates cross-linking of HA, which is encapsulated and released in a time-delayed manner. Also provided are methods for treating or augmenting tissue using such compositions.

The present invention is directed to compositions and methods for delivering a tissue scaffold comprising a perfluorocarbon emulsion to an individual in need of tissue expansion.

The present disclosure relates to surgical grafts for replacing nipples and areolas lost to disease or trauma with surgical grafts of decellularized donor nipples and areolas and to placing and recellularizing such grafts. The disclosure further provides methods for decellularizing epidermis. The decellularized epidermis can be used as a protective cover for skin wounds.

The present invention relates to a method of manufacturing collagen for restoring cartilage tissue usable for a joint in an injection manner, and a usage method thereof. The present invention provides a method of obtaining a high-concentration collagen-solution injection by aseptically filling an injection container with collagen separated from pig skin tissue, and a method of using the high-viscosity collagen loaded into the injection container for the purpose of cartilage restoration. Cartilage tissue regeneration is effectively induced when tissue restoration is implemented with respect to a cartilage-deficient portion using collagen, which is a biocompatible material, in a form that is capable of being injected into an application site with an injection needle without a surgical incision. Accordingly, restoration and regeneration of cartilage are easily and quickly induced in an animal, excluding a human, while relieving the burden related to surgery.