A skin-substitute is constructed by homogenizing an acellular dermal tissue matrix into a slurry, pouring the slurry into a mold, and lyophilizing the slurry.

The present invention describes neutral pH soluble collagen-glycosaminoglycan compositions and methods for augmenting soft tissue defects using the compositions. Soft tissue defects include dermal wrinkles and dermal folds, dermal contour unevenness and laxity and subdermal volume deficiencies. The compositions may also be used for and promoting cellular growth and stimulating tissue regeneration.

Autografts are produced using material harvested from the patient without creation of a new wound. For example, material is harvested from the patient's very wound to which the autograft is to be applied.

The present invention concerns a tissue-engineered medical device, as well as a method for the production said medical device, comprising the following steps: providing a polymer scaffold comprising a mesh comprising polyglycolic acid, and a coating comprising poly-4-hydroxybutyrate; application of a cell suspension containing preferably human cells to the polymer scaffold; placement of the seeded polymer scaffold in a bioreactor and mechanical stimulation by exposure to a pulsatile flux of incremental intensity, thereby forming an extracellular matrix; mounting of the graft on a conduit stabilizer and incubation in cell culture medium; decellularisation of the graft in a washing solution; nuclease treatment of the graft; and rinsing of graft. The invention further comprises and various steps of quality control of the tissue-engineered medical device.

An implantable medical product and method of use for substantially reducing or eliminating harsh biological responses associated with conventionally implanted medical devices, including inflammation, infection and thrombogenesis, when implanted in in a body of a warm blooded mammal. The bioremodelable pouch structure is configured and sized to receive, encase and retain an electrical medical device therein and to allow such device to be inserted into the internal region or cavity of the pouch structure; with the pouch structure formed from either: (a) first and second sheets, or (b) a single sheet having first and second sheet portions. After receiving the electrical device, the edges around the opening are closed by suturing or stapling. The medical device encased by the bioremodelable pouch structure effectively improves biological functions by promoting tissue regeneration, modulated healing of adjacent tissue or growth of new tissue when implanted in the body of the mammal.

A fibrous birth tissue composition fabricated from placental tissue is provided. Methods of processing a mammal’s placental tissue to form a fibrous birth tissue composition are provided. Regenerative methods are also provided.

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a fluid containing at least one agent to produce a tissue matrix with variable mechanical and/or biological properties

The present disclosure includes systems, methods, kits, and individual tools (e.g., trial sizers and delivery devices) for medical procedures involving a soft-tissue allograft for the correction of skeletal impairments (e.g., misalignments, arthritis, etc.).

The invention relates to a method for manufacturing a three-dimensional medical device from an acellular biological matrix characterized in that it comprises at least the following sequence of steps:

a/ wetting an acellular biological matrix with a liquid, and

b/ shaping the wet acellular biological matrix so that it takes on a three-dimensional shape.

The invention also relates to the obtained three-dimensional medical device and its use as an implant.

Graft materials and devices for surgical breast procedures, as well as methods of making graft devices, are described.