Provided herein are drug delivery devices, comprising a scaffold comprising one or more biocompatible materials, one or more chambers containing a plurality of cells, one or more membranes, and one or more nutrient supplementation systems. Also provided are methods of treating or preventing diseases and disorders in a subject in need thereof, comprising administering to the subject the drug delivery devices disclosed herein, and methods of making the drug delivery devices disclosed herein.

An example medical device is disclosed. The example medical device includes a tubular scaffold. The scaffold includes a longitudinal axis, an inner surface and an outer surface. The medical device also includes a flexible valve extending radially inward from the inner surface of the scaffold. The valve includes an annular chamber extending circumferentially around the inner surface of the scaffold and is configured to shift from a closed configuration to an open configuration.

Tissue prostheses having a base structure and a physiological sensor system. The tissue prostheses are adapted and configured to induce remodeling of damaged tissue and regeneration of new tissue and concurrently detect and monitor physiological characteristics when implanted in the subject.

A multilayer scaffold device that includes a luminal electrospun layer, the luminal electrospun layer configured to provide a suitable environment to induce epithelium formation on the scaffold, an exterior electrospun layer, the exterior electrospun layer located radially exterior to the luminal electrospun layer, the exterior electrospun layer configured to induce formation of non-epithelial tissue; and at least one intermediate layer interposed between the luminal electrospun layer and that exterior electrospun layer, the intermediate layer configured to organize the formation of the respective epithelial tissue and the non-epithelial tissue.

The present invention provides an organ production method including a step of tissue-specifically removing a first portion of an organ of a non-human animal partway through development thereof; a step of transplanting, into a region from which the first portion has been removed, an organ precursor cell which is allogeneic or xenogeneic to the non-human animal; and a step of advancing development of the organ, which is a step in which the transplanted organ precursor cell is differentiated and matured to form a part of the organ.

A method for preparing a biocompatible tissue for revitalization thereof, wherein such tissue has an essentially tubular shape. The method provides inserting a support that mainly extends along a longitudinal extension axis inside the cavity defined by the tissue and performing on the outer and/or inner surface of the tissue a plurality of holes spread out on at least one of the generatrixes of the tissue. Holes are made with a depth which occupies at least a part of the thickness of the tissue.

An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at the blood flow surface of the stent.

A sheet structure comprising two joined extracellular matrix (ECM) tissue or sheet layers and a physiological sensor disposed therebetween; the ECM tissue being derived from a mammalian tissue source that includes small intestine submucosa (SIS), urinary bladder submucosa (UBS), stomach submucosa (SS), urinary basement membrane (UBM), liver basement membrane (LBM), amniotic membrane, mesothelial tissue, placental tissue and cardiac tissue.

An organ for transplantation having a kidney, a ureter, and a urinary bladder and an organ structure in which a first ureter, a first urinary bladder, a second ureter and a second urinary bladder are sequentially connected to a kidney can produce urine and excrete the produced urine, and thus is useful for transplantation.

Described are methods and compositions for treatment of reproductive or urogenital mucosal tissue damage using Extracellular Matrix (ECM) solution and, particularly, Extracellular Matrix Hydrogel (ECMH) solution delivered to the target site for tissue repair, restoration, remodeling, or reconstruction.