Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

The present application relates to use of transglutaminases to treat various tissue matrix products. The methods can include application of a transglutaminase to a partially denatured collagen-containing tissue matrix and implantation of the tissue matrix. The transglutaminase can facilitate adhesion with another collagen-containing tissue matrix, tissue surrounding the tissue matrix after implantation, or both.

The present disclosure provides a tissue product comprising a tissue sheet. The sheet can be formed from a plurality of tissue matrix fragments.

Compositions including a decellularized and enzymatically solubilized amnionic membrane (AM) hydrogel, methods for making such compositions, and methods for their use are disclosed.

A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.

The disclosure relates to an expandable scaffold and a method for fabricating the scaffold. The expandable scaffold includes a three-dimensional porous structure comprising a composite material composed by a first material and a second material. The 3D porous structure has a tunable expansion capacity. When applied in a liquid, the 3D porous structure may uptake the liquid and expand from an original volume to an expansion volume up to 1000 times of the original volume. The 3D porous structure may be formed by a plurality of layers of the composite material, and architecture and shape of the layers of the composite material are arranged in accordance with a shape and a size of the expansion volume. Applications of the scaffold may include a bone or soft tissue regeneration system or a bleed stopping device.

The present disclosure provides devices and methods for treating breasts. The devices can include an acellular tissue matrix having a predefined shape that allows for complete or enhanced coverage of an anterior portion of a breast implant or tissue expander or to support an implant and/or surrounding tissues.

The present application relates to a method and device for processing tissue. The method and device allow for machining of soft tissue samples to produce uniform shapes (e.g., uniform thicknesses) or reliably produce alterations such as openings or holes in soft tissue products. The method and device can alternatively or additionally be used to process tissue to produce particulates with desired properties.

Provided herein are enzymatically decellularized cells, and methods of producing said cells, that can be used in a scaffold. The scaffolds featured herein are biocompatible and can comprise decellularized cells that have been modified to express a bioactive agent or molecule.

A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.