The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component.

An iron-based biodegradable component includes an iron element of 60 to 99.5 parts by weight and modifying material of 0.5 to 40 parts by weight, wherein the modifying material includes at least one of a zinc element of 0.1 to 5 parts by weight and a biodegradable ceramic material of 0.1 to 40 parts by weight.

Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.

The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component.

The present invention relates to an implant having a multilayered coating comprising a porous titanium-based layer on the implant, an optional interface titania layer on and/or in the porous titanium-based layer and a bioactive glass layer on and/or in the porous structure formed by the titanium-based and titania layer(s); as well as to a process for preparing an implant having a multilayered coating.

Provided are a method for rapidly producing a calcium phosphate molded article having high strength with high shaping precision, a calcium phosphate molded article produced by the method, and a material for transplantation. Disclosed is a method for producing a calcium phosphate molded article, the method including: step (a) of forming a layer containing a calcium phosphate powder having a ratio of the numbers of atoms of Ca/P of 1.4 to 1.8 on a substrate; and step (b) of producing a calcium phosphate molded article by jetting an organic acid solution having a pH of 3.5 or lower and including an organic acid whose calcium salt has a solubility in water of 1 g/100 mL or less, through a nozzle unit into a liquid droplet state, thereby dropping the organic acid solution onto the layer containing a calcium phosphate powder formed in step (a).

Disclosed are a thiolated polysaccharide derivative hydrogel, a preparation method therefor, and use thereof. The thiolated polysaccharide derivative hydrogel is a thiolated hyaluronic acid polysaccharide derivative hydrogel or a thiolated chitin/chitosan derivative hydrogel. The thiolated hyaluronic acid polysaccharide derivative hydrogel is a polysaccharide hydrogel formed of one or two of thiolated hyaluronic acid derivatives and an aqueous solvent, and the thiolated chitin/chitosan derivative hydrogel is a polysaccharide hydrogel formed of one or two of thiolated chitin/chitosan derivatives and an aqueous solvent. The thiolated polysaccharide derivative hydrogel of the present invention is suitable for being used as a vitreous body substitute, and as the vitreous body substitute, can improve a shock absorption function, and can maintain the shape of an eyeball and press a retina in situ due to a good self-healing function and resilience.

The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.

Disclosed are a patch comprising a metal-organic framework, in particular a silicone patch comprising a metal-organic framework and a silicone composition, and an artificial skin comprising a metal-organic framework. The patch and artificial skin according to one aspect of the present invention have wound healing properties such as a reduction in the size of a scar area when attached to a scar on the skin, and in particular have an excellent wound healing effect that reduces the scar area by about 50% compared to a control group to which a patch or artificial skin not containing a metal-organic framework is attached, such that the present invention can be used as a patch for cell regeneration or skin would healing, in particular as a silicone patch, and furthermore, can be used as artificial skin.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.