The present invention relates generally to the field of bone graft substitutes and methods for making the same, particularly the invention relates to bone graft substitutes for use in dental or orthopaedic implants. The bone graft substitutes described herein comprise a silicate based material. The silicate based material is a silicate network with a porous structure. The silicate network has one or more metal cations incorporated therein. Preferably a phosphate is also incorporated into the silicate network. The bone graft substitute may have a low density, preferably a density of less than 1.1 g/cm.sup.3. The bone graft substitute may be an aerogel or a cryogel.

Various embodiments disclosed relate to curable calcium phosphate compositions for use with porous structures and methods of using the same. In various embodiments, the present invention provides a curable calcium phosphate composition or a cured product thereof, with the curable calcium phosphate composition including calcium phosphate and a perfusion modifier. In various embodiments, the present invention provides an apparatus comprising a porous structure at least partially in contact with the curable calcium phosphate composition or a cured product thereof. The porous structure can include a porous substrate including a plurality of ligaments that define pores of the porous substrate, and a biocompatible metal coating on the plurality of ligaments of the porous substrate.

Various embodiments disclosed relate to curable calcium phosphate compositions for use with porous structures and methods of using the same. In various embodiments, the present invention provides a curable calcium phosphate composition or a cured product thereof, with the curable calcium phosphate composition including calcium phosphate and a perfusion modifier. In various embodiments, the present invention provides an apparatus comprising a porous structure at least partially in contact with the curable calcium phosphate composition or a cured product thereof. The porous structure can include a porous substrate including a plurality of ligaments that define pores of the porous substrate, and a biocompatible metal coating on the plurality of ligaments of the porous substrate.

A highly safe and inexpensive bone repair material that stably exhibits high antibacterial activity for a long time in a living body by supporting a large amount of an iodine ion and is excellent in apatite forming ability and preservability. The material includes a substrate made of titanium or titanium alloy and a titanate film on a surface of the substrate, the film composed of a large number of crystalline masses having a crystal structure and containing a calcium ion and an iodine ion, wherein the mass contains layers having a TiO skeleton and the calcium and the iodine ions adsorbed between the layers.

The present disclosure provides methods of forming interlayer tissue cushions (e.g., submucosal cushions) using shear-thinning hydrogels comprising an anionic polysaccharide and layered silicate and subsequent use of the cushions for removing protrusions (e.g., lesions, such as polyps or tumors) from above the cushions. Further provided are uses, methods of treatment, and kits.

The object of the invention is a porous alumina ceramic matrix grafted with an antibiotic, in particular vancoymicin, as well as its use in therapy. The invention also relates to a prosthesis or an implant using this matrix. The invention also relates to a method for preparing a matrix according to the invention.

The invention relates to a biocompatible molded part for supporting new bone formation, in particular the reformation of a jaw bone or a jaw bone portion in a mammal, preferably a human, wherein the molded part is suitable to be placed on the jaw bone and is designed as a solid body. The invention also relates to a composition for producing a biocompatible molded part, a method for producing a biocompatible molded part, a use of a biocompatible molded part and a kit comprising a plurality of molded parts.

A method of treating a bacterial infection including bacteria that have become resistant to an antibiotic in a subject in need thereof is provided. The method includes administering to the subject a safe and therapeutically effective amount of the antibiotic and a reviving agent selected from the group consisting of glass-ceramic particles, silver ions, and combinations thereof. The reviving agent restores antibiotic activity to the antibiotic against the bacteria.

Disclosed is an implanted device, comprising a device base body and an active drug, wherein the device base body is pure zinc and/or a zinc alloy, the zinc content in the device base body is 0.1-100%, and the active drug comprises anti-allergic drugs. After the implantation of the implanted device into the human body, the surrounding tissues of the implant would not have a clear hypersensitive reaction due to the presence of the anti-allergic drugs, and the implanted device can be used to be implanted into the body for supporting organ chambers, to fill the hollow chambers of the organs and tissues or as orthopaedic implants etc.

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.