The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for tamponade hemostasis of bone or cartilage.

A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture is compatible with biologic function.

A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture is compatible with biologic function.

The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process. Calcium containing particles can be isolated from autologous bone, allogenic bone or xenogeneic bone but can be also isolated from minerals or be prepared by synthesis. Preferable Calcium containing particles consist of β-tricalcium phosphate which is resorbable or natural bone powder, preferably of human or porcine origin. The particles described in the present invention have particle size smaller than 400 microns, or more preferably smaller than 200 microns, to make it possible to handle in printing nozzle without clogging and to obtain a good resolution. Cellulose nanofibrils can be produced by bacteria orbe isolated from plants. They can be neutral, charged or oxidized to be biodegradable. The bioink can be additionally supplemented by other biopolymers which provide crosslinking. Such biopolymers can be alginates, chitosans, modified hyaluronic acid or modified collagen derived biopolymers.

This invention corresponds to a prosthesis for total or hip resurfacing replacement, which comprises a prosthetic femoral head made of highly cross-linked polyethylene, with a diameter ranging from 38 mm to 64 mm, to articulate with a cup or acetabular component made of metal. When the invention applies to total hip replacement, the polyethylene head includes a metal core, which contains inside the female counterpart (14) to mate with the male counterpart (13) of a Morse taper, located at the upper end of the femoral component. The use of this type of head for total hip replacement, articulated with an ultra-polished acetabular cup, reduces the risk of dislocation, transmits less angular and torque forces to the Morse taper than large metal heads, and avoids the problems related to the metal-metal bearing or with the use of large metal heads with thin polyethylene. When the invention relates to hip resurfacing replacement, the highly cross-linked polyethylene femoral head has a lower polyethylene extension or stem with or without internal metal reinforcement (151) or a metal stem integrated into a metal-back (152). Using these types of heads for hip resurfacing replacement heads eliminates the problems associated with metal-on-metal resurfacing replacements.

This invention corresponds to a prosthesis for total or hip resurfacing replacement, which comprises a prosthetic femoral head made of highly cross-linked polyethylene, with a diameter ranging from 38 mm to 64 mm, to articulate with a cup or acetabular component made of metal. When the invention applies to total hip replacement, the polyethylene head includes a metal core, which contains inside the female counterpart (14) to mate with the male counterpart (13) of a Morse taper, located at the upper end of the femoral component. The use of this type of head for total hip replacement, articulated with an ultra-polished acetabular cup, reduces the risk of dislocation, transmits less angular and torque forces to the Morse taper than large metal heads, and avoids the problems related to the metal-metal bearing or with the use of large metal heads with thin polyethylene. When the invention relates to hip resurfacing replacement, the highly cross-linked polyethylene femoral head has a lower polyethylene extension or stem with or without internal metal reinforcement (151) or a metal stem integrated into a metal-back (152). Using these types of heads for hip resurfacing replacement heads eliminates the problems associated with metal-on-metal resurfacing replacements.

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.

A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

The present invention provides an orthopedic implant comprising a continuous reinforced composite filament in a freely predetermined fiber orientation in multiple continuous successive layers, wherein the continuous reinforced composite filament comprises a bioabsorbable polymer matrix and a continuous bioabsorbable reinforcing fiber or fiber bundle, and whereby the continuous bioabsorbable reinforcing fiber or fiber bundle of consecutive layers at least partly intermingles and/or intertwines forming a three dimensionally interlocked continuous fiber structure.

Bone Composite and Compositions, particularly multicomponent or multipart compositions, are for the preparation of bone constructs for use in trauma, or cancer patients for example. The multipart compositions are based around combinations of fibrinogen, thrombin, hydrogels and calcium/phosphorous salts. The multipart compositions are capable of being printed to yield bone constructs using a 3D printing process to produce accurate and precise bone constructs of a desired geometry.