Provided are synthetic bone graft substitutes that include bioactive glass and a carrier. Synthetic bone graft substitutes may include bioactive glass, glycerol and polyethylene glycol. Also provided are bone graft substitutes that include collagen and bioactive glass particles. Example bone graft substitutes may include collagen and bioactive glass particles. Other example embodiments may include Type I Bovine Collagen, an angiogenic agent, such as hyaluronic acid, and bioactive glass. Further provided are methods that include administering the present bone graft substitutes to a mammal, e.g., by surgical insertion of the bone graft substitute into the mammal, either alone or in conjunction with one or more implant devices. Further provided are kits that include the present bone grafts.

A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

A prosthesis for a synovial joint arthroplasty within a human body is provided. The prosthesis includes a first prosthetic component, the first prosthetic component including a first surface and the first prosthetic component being formed of a copolymer elastomer compound, the copolymer elastomer compound including a thermoplastic elastomer, a plurality of long glass fibers, the long glass fibers being randomly dispersed throughout the thermoplastic elastomer, a number of the plurality of long glass fibers protruding outward from the first surface of the first prosthetic component and a plurality of beads, the beads being randomly dispersed throughout the thermoplastic elastomer, a number of the plurality of beads protruding outward from the first surface of the first prosthetic component; a second prosthetic component, the second prosthetic component including a second surface, the second surface of the second prosthetic component positioned proximate the first surface of the first prosthetic component to engage the plurality of long glass fibers protruding from the first surface of the first prosthetic component and the plurality of beads protruding from the first surface of the first prosthetic component allowing the second surface of the second prosthetic component to slide relative to the first surface of first prosthetic component while contacting the plurality of long glass fibers protruding outward from the first surface of the first prosthetic component and the plurality of beads protruding outward from the first surface of the first prosthetic component, a gap, the gap created by the voids between the second surface of the second prosthetic component, the first surface of the first prosthetic component and the plurality of long glass fibers that protrude outward from the first surface of the first prosthetic component and between the second surface of the second prosthetic component, the first surface of the first prosthetic component and the plurality of beads that protrude outward from the first surface of the first prosthetic component, the gap further disposed between the first surface of the first prosthetic component and the second surface of the second prosthetic component to allow the passage of fluid between the first surface of the first prosthetic component and the second surface of the second prosthetic component, a first trough, the first trough formed as the plurality of long glass fibers protruding outward from the first surface are forced into the thermoplastic elastomer as the prosthesis is loaded, the first trough positioned proximate the plurality of long glass fibers and extending a perimeter of the plurality of long glass fib

A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.

A method for treating a bone, the method comprising: selecting at least one reinforcing element to be combined with an injectable matrix material so as to together form a composite implant capable of supporting the bone; positioning the at least one reinforcing element in a cavity in the bone; flowing the injectable matrix material into the cavity in the bone so that the injectable matrix material interfaces with the at least one reinforcing element; and transforming the injectable matrix material from a flowable state to a non-flowable state so as to establish a static structure for the composite implant, such that the composite implant supports the adjacent bone.

In alternative embodiments, provided are products of manufacture such as medical or dental devices, e.g., bone implants, having zinc phosphate (ZnP) coatings prepared on zinc (Zn), magnesium (Mg), and iron (Fe) based biodegradable metals and other non-biodegradable substrates, e.g., stainless steel, titanium and its alloys, cobalt-chrome alloys, nickel titanium alloys, to improve surface biocompatibility and provide antibacterial properties, and to enhance vascularization, and methods of making and using them. In alternative embodiments, also provided are methods to form ZnP coatings, including ZnP coatings with a porous surface, on metal surfaces such as zinc surfaces, and Zn-, Mg-, and Fe-based biodegradable metals, and other non-biodegradable substrates.

Shown and described is an insulin-mimetic as an inductive agent for cartilage and/or bone repair is disclosed. Sodium tungstate (Na.sub.2WO.sub.4) was utilized as an inductive factor to enhance human mesenchymal stem cell (MSC) chondrogenesis. The chondrogenic differentiation of MSCs was enhanced in the presence of low concentrations of Na.sub.2WO.sub.4 as compared to control, without Na.sub.2WO.sub.4. Also disclosed is a composite scaffold capable of supporting cell and tissue growth. The composite scaffold could include zinc oxide and polycaprolactone.

Shown and described is an insulin-mimetic as an inductive agent for cartilage and/or bone repair is disclosed. Sodium tungstate (Na.sub.2WO.sub.4) was utilized as an inductive factor to enhance human mesenchymal stem cell (MSC) chondrogenesis. The chondrogenic differentiation of MSCs was enhanced in the presence of low concentrations of Na.sub.2WO.sub.4 as compared to control, without Na.sub.2WO.sub.4. Also disclosed is a composite scaffold capable of supporting cell and tissue growth. The composite scaffold could include zinc oxide and polycaprolactone.

This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.

A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.

A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.