The invention relates to a flexible barrier membrane (1) comprising at least one first layer (2a) of polyurethane, and at least one second layer (20) of material(s), which is incorporated into the first layer (2a) of polyurethane by a modification of at least one surface of the at least one layer of polyurethane. The at least one material of the at least one second layer is selected from the materials including inorganic silicon oxide, organic silicon oxide and a barrier polymer. The invention also relates to a method for producing the flexible barrier membrane (1).

Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.

Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.

A pedicle screw implant construct kit, comprising at least one pedicle screw, at least one collar comprising a recess for receiving a rod, the collar configured to be coupled to a head of the pedicle screw, an elongated rod for connecting the collar to one more additional collars to couple between the pedicle screw and one or more additional screws, and a locking ring sized to be positioned over at least a distal portion of the collar to restrain relative movement of the screw head and rod by exerting radial compression force onto the collar. In some embodiments, the components of the kit are comprised of carbon reinforced composite material, optionally with no radiation blocking material. In some exemplary embodiments of the invention, the kit includes two locking rings on a collar, optionally both below the rod.

The present invention relates to a method for preparing a medical material for replacing a hard tissue defect and a medical material produced therefrom. More specifically, in the present invention, powders of bioactive glass are press-molded, and are then subjected to a first heat treatment at a relatively low temperature below the glass transition temperature of bioactive glass. Then, the resultant is processed into a desired shape and then subjected to a second heat treatment at a temperature higher than the glass transition temperature of bioactive glass. Accordingly, the present invention provides a medical material which can be customized to a desired shape of a hard tissue defect in a living body and minimize thermal shock, and which is capable of exhibiting a bone fusion property, while overcoming the low compressive strength drawback of hydroxyapatite, which is an existing hard tissue replacement material currently in use.

A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

Various examples are provided for magnetic particle imbedded nanofibrous membranes. In one example, among others, a nanofibrous membrane includes one or more electrospun nanofibers forming form a layer of nanofibers, and a plurality of magnetic nanoparticles embedded in the one or more electrospun nanofibers. In another example, a method includes generating one or more electrospun nanofibers including magnetic nanoparticles from one or more nozzles positioned over a substrate to form a magnetic nanofibrous layer, and affixing the magnetic nanofibrous layer to a support structure. In another example, a system includes a magnetic nanofibrous membrane affixed to a support structure, and a magnetic field generator configured to generate a magnetic field that passes through the magnetic nanofibrous membrane.

Various examples are provided for magnetic particle imbedded nanofibrous membranes. In one example, among others, a nanofibrous membrane includes one or more electrospun nanofibers forming form a layer of nanofibers, and a plurality of magnetic nanoparticles embedded in the one or more electrospun nanofibers. In another example, a method includes generating one or more electrospun nanofibers including magnetic nanoparticles from one or more nozzles positioned over a substrate to form a magnetic nanofibrous layer, and affixing the magnetic nanofibrous layer to a support structure. In another example, a system includes a magnetic nanofibrous membrane affixed to a support structure, and a magnetic field generator configured to generate a magnetic field that passes through the magnetic nanofibrous membrane.

Methods of forming antimicrobial resin compositions comprising silver nanoparticles are disclosed, wherein the resin compositions that are generated exhibit lower initial color, reduced color shift upon storage and reduced levels of spontaneous polymerization. Such methods generally comprise: combining a silver-containing material with a self-cure and dual-cure base resin in situ wherein the base resin does not contain a catalytic amine; and adding a catalytic resin to the mixture of the resin and silver-containing material in order to form the final cured resin. Antimicrobial polymeric materials formed by said methods are also disclosed.