Implant comprising composite powder with microstructured particles, obtained by a process in which large particles are bonded to small particles, wherein the large particles have a mean particle diameter in the range from 10 m to 10 mm, the large particles comprise at least one polymer, the small particles are arranged on the surface of the large particles and/or are non-homogeneously spread within the large particles, the small particles comprise a calcium salt, the small particles have a mean particle size in the range from 0.01 m to 1.0 mm,
wherein the particles of the composite powder have a mean particle size d50 in the range from 10 m to less than 200 m and the fine fraction of the composite powder is less than 50 vol %.

Therefore, the subject matter of the invention further are implants obtained by selective laser sintering of a composition comprising a composite powder, especially as an implant for applications in the field of neuro, oral, maxillary, facial, ear, nose and throat surgery as well as of hand, foot, thorax, costal and shoulder surgery.

A method of manufacturing a resorbable, macroporous bioactive glass scaffold comprising approximately 15-45% CaO, 30-70% SiO.sub.2, 0-25% Na.sub.2O, 0-17% P.sub.2O.sub.5, 0-10% MgO and 0-5% CaF.sub.2 by mass percent, produced by mixing with pore forming agents and specified heat treatments.

A method of manufacturing a resorbable, macroporous bioactive glass scaffold comprising approximately 15-45% CaO, 30-70% SiO.sub.2, 0-25% Na.sub.2O, 0-17% P.sub.2O.sub.5, 0-10% MgO and 0-5% CaF.sub.2 by mass percent, produced by mixing with pore forming agents and specified heat treatments.

A pedicle screw implant construct kit, comprising at least one pedicle screw, at least one collar comprising a recess for receiving a rod, the collar configured to be coupled to a head of the pedicle screw, an elongated rod for connecting the collar to one more additional collars to couple between the pedicle screw and one or more additional screws, and a locking ring sized to be positioned over at least a distal portion of the collar to restrain relative movement of the screw head and rod by exerting radial compression force onto the collar. In some embodiments, the components of the kit are comprised of carbon reinforced composite material, optionally with no radiation blocking material. In some exemplary embodiments of the invention, the kit includes two locking rings on a collar, optionally both below the rod.

Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.

A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.

The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.

A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture is compatible with biologic function.

A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture is compatible with biologic function.

A temperature-responsive hydrogel exhibiting a high viscosity at a high temperature, a low viscosity at a low temperature and a high ratio of the viscosity at a high temperature to the viscosity at a low temperature produced by mixing of an aqueous solution containing a polyalkylene glycol having an average molecular weight of 20,000 to 10,000,000 with an aqueous dispersion containing a silicate salt so as to achieve a specific compositional range of the components in the hydrogel, at a mass concentration of A of 0.01 to 1.5% by mass, at a mass concentration of A of 0.1 to 0.4% by mass and at a mass concentration of B of 0.5 to 10% by mass, at a mass concentration of B of 1 to 5% by mass, with the mass ratio R of A to B (R=(mass of A)/(mass of B)) within the range of 0.01 to 0.5.