Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling.

Disclosed is a flexible substrate/liquid electrolyte viscous composite material and preparation method therefor. The preparation method includes: adding a particular percentage by weight of a flexible substrate to a liquid electrolyte solution having a particular concentrate; fully stirring the solution at a particular temperature to dissolve and evenly disperse the substrate, so as to obtain a viscous liquid; and then standing the viscous liquid at a particular temperature for a particular period of time to obtain the material. The material has viscosity due to which the material can actively adhere to the surface of tissue of an organ, the mechanical property matching cardiac muscle, biocompatibility and security, and is used for treating acute and chronic myocardial infarction and heart failures, inhibiting the reconstruction, thinning, and fiberization of a ventricular wall, and improving the myocardial function. In addition, the material also features conductivity, in vivo degradability, and the like.

There is a need for methods that can produce piezoelectric composites having suitable physical characteristics and also optimized electrical stimulatory proper-ties. The present application provides piezo-electric composites, including tissue-stimu-lating composites, as well as methods of making such composites, that meet these needs. In embodiments, methods of making a spinal implant are provided. The methods suitably comprise preparing a thermoset, thermoplastic or thermoset/thermoplastic, or copolymer polymerizable matrix, dispersing a plurality of piezoelectric particles in the polymerizable matrix to generate dispersion, shaping the dispersion, inducing an electric polarization in the piezoelectric particles in the shaped dispersion, wherein at least 40% of the piezoelectric particles form chains.

A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.

The invention is a prosthetic joint, for example, knee joint, including a first joint component which is preferably polyetheretherketone containing barium sulphate and a second joint component which is preferably a polyolefin.

The invention is a prosthetic joint, for example, knee joint, including a first joint component which is preferably polyetheretherketone containing barium sulphate and a second joint component which is preferably a polyolefin.

The invention relates to the use of inhibiting calcium carbonate as an additive for a composition used in an implant, the composition containing at least one polymer different from cellulose, and the inhibiting calcium carbonate being obtainable by a method in which calcium carbonate particles are coated with a composition that contains, each relative to its total weight, a mixture of at least 0.1 wt.-% of at least one calcium complexing agent and/or at least one conjugated base which is an alkali metal salt or calcium salt of a weak acid, together with at least 0.1 wt.-% of at least one weak acid.

The invention further relates to an implant comprising a composition that contains at least one polymer different from cellulose and inhibiting calcium carbonate, said inhibiting calcium carbonate being obtainable by a method in which calcium carbonate particles are coated with a composition that contains, each relative to its total weight, a mixture of at least 0.1 wt.-% of at least one calcium complexing agent and/or at least one conjugated base which is an alkali metal salt or calcium salt of a weak acid, together with at least 0.1 wt.-% of at least one weak acid.