A medical implant comprising a plurality of layers, each layer comprising a polymer and a plurality of uni-directionally aligned continuous reinforcement fibers.

Devices prepared from resins are disclosed. In one aspect, a spinal cage is disclosed for implantation between two adjacent vertebrae, the spinal cage formed from a polymer composition comprising a polyetherimide, polyether ether ketone or other biocompatible resin, the spinal cage formed from a process comprising: receiving an input relating to design specifications of the spinal cage; and causing formation of at least a portion of the spinal cage based upon the input and using one or more of an additive and subtractive process.

Devices prepared from resins are disclosed. In one aspect, a spinal cage is disclosed for implantation between two adjacent vertebrae, the spinal cage formed from a polymer composition comprising a polyetherimide, polyether ether ketone or other biocompatible resin, the spinal cage formed from a process comprising: receiving an input relating to design specifications of the spinal cage; and causing formation of at least a portion of the spinal cage based upon the input and using one or more of an additive and subtractive process.

A semi-synthetic hybrid material having a pH from 7 to 7.4 includes an inorganic fraction and a cross-linked organic fraction. The method for producing this material, and osteosynthesis devices or implants made of semi-synthetic hybrid material are also described.

A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process. Calcium containing particles can be isolated from autologous bone, allogenic bone or xenogeneic bone but can be also isolated from minerals or be prepared by synthesis. Preferable Calcium containing particles consist of -tricalcium phosphate which is resorbable or natural bone powder, preferably of human or porcine origin. The particles described in the present invention have particle size smaller than 400 microns, or more preferably smaller than 200 microns, to make it possible to handle in printing nozzle without clogging and to obtain a good resolution. Cellulose nanofibrils can be produced by bacteria orbe isolated from plants. They can be neutral, charged or oxidized to be biodegradable. The bioink can be additionally supplemented by other biopolymers which provide crosslinking. Such biopolymers can be alginates, chitosans, modified hyaluronic acid or modified collagen derived biopolymers.

An actuator device that includes at least one fiber, and at least one first coating is disclosed. The first coating encloses the at least one fiber. The actuator device may include a plurality of fibers and/or a conducting material. The coatings may enclose the plurality of fibers, or each individual fiber. The coatings may provide moisture protection, UV protection, saline protection, and oxidation protection. The coating may be thermally and electrically conducting or insulating, depending on the specific function and environment of the actuator device.

Anti-biofilm osseointegrating implantable devices are made by additive manufacturing. A powder formulation is made that includes a resin such as a polyarylether ketone such as PEEK, and a zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The powder formulation also may include a porogen to control the porosity of the resulting three-dimensional implant device. The devices, which are osseointegrating, may include metal-loaded zeolite so as to elute antimicrobial metal ions in a therapeutically effective amount when implanted into a body and exposed to bodily fluid.

Anti-biofilm osseointegrating implantable devices are made by additive manufacturing. A powder formulation is made that includes a resin such as a polyarylether ketone such as PEEK, and a zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The powder formulation also may include a porogen to control the porosity of the resulting three-dimensional implant device. The devices, which are osseointegrating, may include metal-loaded zeolite so as to elute antimicrobial metal ions in a therapeutically effective amount when implanted into a body and exposed to bodily fluid.