[Problem to be Solved] To provide a porous composite that has excellent uniform dispersability of OCP and that comprises OCP and collagen in a sufficiently mixed state; and a bone regeneration material comprising the porous composite. [Means for Solution] A porous composite comprising octacalcium phosphate and collagen, characterized in that in an image obtained by enlarging a 5.0-mm5.0-mm range of a plane of the porous composite 15 times with a scanning electron microscope (SEM), agglomerated particles of octacalcium phosphate have a fractal dimension (D) of 0.70 or more; and the area of c) portions consisting of collagen accounts for 5% or less of the total area of a) portions consisting of agglomerated particles of octacalcium phosphate, b) portions consisting of octacalcium phosphate microparticles and collagen, and the c) portions consisting of collagen.

[Problem to be Solved] To provide a porous composite that has excellent uniform dispersability of OCP and that comprises OCP and collagen in a sufficiently mixed state; and a bone regeneration material comprising the porous composite. [Means for Solution] A porous composite comprising octacalcium phosphate and collagen, characterized in that in an image obtained by enlarging a 5.0-mm5.0-mm range of a plane of the porous composite 15 times with a scanning electron microscope (SEM), agglomerated particles of octacalcium phosphate have a fractal dimension (D) of 0.70 or more; and the area of c) portions consisting of collagen accounts for 5% or less of the total area of a) portions consisting of agglomerated particles of octacalcium phosphate, b) portions consisting of octacalcium phosphate microparticles and collagen, and the c) portions consisting of collagen.

The present invention relates to a flowable bone graft material including an inorganic composition comprising calcium phosphate having a particle size of about 100 m to about 1,000 m, bioactive glass, and one or more biocompatible polymers comprising carboxymethyl cellulose and a fluid.

The present invention relates to a flowable bone graft material including an inorganic composition comprising calcium phosphate having a particle size of about 100 m to about 1,000 m, bioactive glass, and one or more biocompatible polymers comprising carboxymethyl cellulose and a fluid.

The present invention relates to a flowable bone graft material including an inorganic composition comprising calcium phosphate having a particle size of about 100 m to about 1,000 m, bioactive glass, and one or more biocompatible polymers comprising carboxymethyl cellulose and a fluid.

Embodiments of the disclosure relate to devices (e.g., patches, plugs, beams, plates, screws, rods, granules, spacers, cages, discs, tape devices, or other shape determined by the geometry or anatomy of the site of application) and methods of use thereof.

Embodiments of the disclosure relate to devices (e.g., patches, plugs, beams, plates, screws, rods, granules, spacers, cages, discs, tape devices, or other shape determined by the geometry or anatomy of the site of application) and methods of use thereof.

The disclosure relates to a scaffold for tissue regeneration and methods for fabricating the scaffold. The scaffold includes a three-dimensional structure composed by alternating layers of various materials including a first medium, a second medium and a third medium. The first medium includes bone particles each having a size of 1 nm to 100 mm with or without organic components. The second medium is a natural or synthetic biocompatible and/or biodegradable polymer. The third medium is a material dissolved in a solvent different than the solvent of the polymer and includes solid particulates alone or in polymeric structures that dissolve when immersed in liquid or gaseous solvent environments or based on temperature differentials. The various materials are arranged according to the shape and the size of a bone gap being generated. The three-dimensional structure has a tunable porosity with interconnected channels and pores along with adjustable dimensions.

The invention provides a cell binding composition comprising a shear thinning gel wherein the shear thinning gel having attached to it one or more cell selective binding agents, or the shear thinning gel having dispersed therein a plurality of gel beads, the gel beads having attached to them one or more cell selective binding agents.

Methods of enriching cells using the compositions and using the cells to treat injury or disease are also provided.

The invention provides a cell binding composition comprising a shear thinning gel wherein the shear thinning gel having attached to it one or more cell selective binding agents, or the shear thinning gel having dispersed therein a plurality of gel beads, the gel beads having attached to them one or more cell selective binding agents.

Methods of enriching cells using the compositions and using the cells to treat injury or disease are also provided.