A hybrid composite and method for producing a polymer network are provided. The hybrid composite includes nanocrystalline hydroxyapatite (nHA) and polyurethane. The method for producing a polymer network includes reacting nanocrystalline hydroxyapatite (nHA) particles with lysine derived triisocyanate (LTI) to form a nHA/LTI hybrid prepolymer and reacting the prepolymer with a thioketal (TK) diol to form a nHA/poly(thioketal urethane) (PTKUR) hybrid polymer network.

Methods for making a biodegradable collagen matrix having increased osteoinductivity and a biodegradable collagen matrix prepared by these methods are provided. In various embodiments, the methods include providing an acidic collagen slurry and mixing it with at least one water soluble and/or hydrophilic bioactive agent under conditions sufficient to cause the collagen slurry to self-assemble into macroscopic collagen fibers and cause the at least one bioactive agent to form a collagen matrix containing the bioactive agent. Conditions sufficient to cause the collagen slurry to self-assembly include raising the pH of the slurry to from about 5 to about a pH of 9 and/or adding bone powder, calcium phosphate, hydroxyapatite, DBM or a mixture thereof to the acidic collagen slurry in order to raise the pH from about 5 to about 9.

Methods for making a biodegradable collagen matrix having increased osteoinductivity and a biodegradable collagen matrix prepared by these methods are provided. In various embodiments, the methods include providing an acidic collagen slurry and mixing it with at least one water soluble and/or hydrophilic bioactive agent under conditions sufficient to cause the collagen slurry to self-assemble into macroscopic collagen fibers and cause the at least one bioactive agent to form a collagen matrix containing the bioactive agent. Conditions sufficient to cause the collagen slurry to self-assembly include raising the pH of the slurry to from about 5 to about a pH of 9 and/or adding bone powder, calcium phosphate, hydroxyapatite, DBM or a mixture thereof to the acidic collagen slurry in order to raise the pH from about 5 to about 9.

Methods for making a biodegradable collagen matrix having increased osteoinductivity and a biodegradable collagen matrix prepared by these methods are provided. In various embodiments, the methods include providing an acidic collagen slurry and mixing it with at least one water soluble and/or hydrophilic bioactive agent under conditions sufficient to cause the collagen slurry to self-assemble into macroscopic collagen fibers and cause the at least one bioactive agent to form a collagen matrix containing the bioactive agent. Conditions sufficient to cause the collagen slurry to self-assembly include raising the pH of the slurry to from about 5 to about a pH of 9 and/or adding bone powder, calcium phosphate, hydroxyapatite, DBM or a mixture thereof to the acidic collagen slurry in order to raise the pH from about 5 to about 9.

Methods and compositions for repair and regeneration of neural tissue are provided. Particularly, methods and compositions for promoting neural tissue wound healing and treatment of traumatic brain injury using porous crystalline calcium carbonate particles and a biocompatible polymer, for example compositions comprising porous coral exoskeleton particles in combination with a biocompatible polymer, and optionally comprising neural growth agents and platelets for application to damaged neural tissue for enhancing neural regrowth and recovered functionality, in, for example, but not limited to, traumatic brain injury (TBI).

Methods and compositions for repair and regeneration of neural tissue are provided. Particularly, methods and compositions for promoting neural tissue wound healing and treatment of traumatic brain injury using porous crystalline calcium carbonate particles and a biocompatible polymer, for example compositions comprising porous coral exoskeleton particles in combination with a biocompatible polymer, and optionally comprising neural growth agents and platelets for application to damaged neural tissue for enhancing neural regrowth and recovered functionality, in, for example, but not limited to, traumatic brain injury (TBI).

A composite dura substitute implant for implantation at a dura defect site having a porous layer that provides an osteoconductive scaffold for bony ingrowth, a porous layer that provides a scaffold for regeneration of collagen at a dura surface, and an intervening layer for preventing cerebrospinal leakage is disclosed. The composite dura substitute implant facilitates regeneration of dura mater and promotes osteointegration with bony tissue. Methods of manufacturing such an implant and methods of treatment using such composite dura substitute implants are further disclosed.

In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) citric acid, a citrate, or an ester of citric acid with (ii) a polyol, and (iii) a monomer comprising one or more alkyne moieties and/or azide moieties. The reaction product, in some instances, comprises a polymer. Further, in some cases, a composition described herein comprises a plurality of polymers. In some embodiments, the polymers are selected to be reactive with one another through a click chemistry reaction scheme to form a polymer network. In another aspect, medical implants and medical devices are described herein, the implants and devices comprising a polymer or polymer network described herein.

In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) citric acid, a citrate, or an ester of citric acid with (ii) a polyol, and (iii) a monomer comprising one or more alkyne moieties and/or azide moieties. The reaction product, in some instances, comprises a polymer. Further, in some cases, a composition described herein comprises a plurality of polymers. In some embodiments, the polymers are selected to be reactive with one another through a click chemistry reaction scheme to form a polymer network. In another aspect, medical implants and medical devices are described herein, the implants and devices comprising a polymer or polymer network described herein.

In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) citric acid, a citrate, or an ester of citric acid with (ii) a polyol, and (iii) a monomer comprising one or more alkyne moieties and/or azide moieties. The reaction product, in some instances, comprises a polymer. Further, in some cases, a composition described herein comprises a plurality of polymers. In some embodiments, the polymers are selected to be reactive with one another through a click chemistry reaction scheme to form a polymer network. In another aspect, medical implants and medical devices are described herein, the implants and devices comprising a polymer or polymer network described herein.