Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.

Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.

A biodegradable composite material or device including at least one biodegradable polymer matrix material and at least one filler component. The material or device has an initial shape and at least one evolved shape. The evolved shape is different from the initial shape. The initial shape is adapted to change towards the evolved shape. The filler component is adapted to accelerate and/or amplify the transformation from the initial shape towards the evolved shape when the external stimulus for transformation is given by physiological conditions. Also a method to control the shape transformation rate of a composite material or device.

A biodegradable composite material or device including at least one biodegradable polymer matrix material and at least one filler component. The material or device has an initial shape and at least one evolved shape. The evolved shape is different from the initial shape. The initial shape is adapted to change towards the evolved shape. The filler component is adapted to accelerate and/or amplify the transformation from the initial shape towards the evolved shape when the external stimulus for transformation is given by physiological conditions. Also a method to control the shape transformation rate of a composite material or device.

A biodegradable composite material or device including at least one biodegradable polymer matrix material and at least one filler component. The material or device has an initial shape and at least one evolved shape. The evolved shape is different from the initial shape. The initial shape is adapted to change towards the evolved shape. The filler component is adapted to accelerate and/or amplify the transformation from the initial shape towards the evolved shape when the external stimulus for transformation is given by physiological conditions. Also a method to control the shape transformation rate of a composite material or device.

Described is a method for the production of substantially spherical calcium phosphate particles that involves subjecting a composition comprising calcium phosphate to dual asymmetric centrifugation (DAC). Also described are products of the method.

Described is a method for the production of substantially spherical calcium phosphate particles that involves subjecting a composition comprising calcium phosphate to dual asymmetric centrifugation (DAC). Also described are products of the method.

Described is a method for the production of substantially spherical calcium phosphate particles that involves subjecting a composition comprising calcium phosphate to dual asymmetric centrifugation (DAC). Also described are products of the method.

A gallium silica glass composition is described. The glass can be used in variety of biomedical applications

A gallium silica glass composition is described. The glass can be used in variety of biomedical applications