A collagen scaffold for the delivery of bioactive agents such as antimicrobials comprising a first collagen matrix layer and a second collagen matrix layer in which the first collagen matrix layer comprises a first bioactive agent physically entrapped in the first collagen matrix layer and the second collagen matrix layer comprises a second bioactive agent chemically attached to the second collagen matrix layer for an initial high concentration elution of antimicrobial from the first collagen matrix layer followed by a sustained release from the second collagen matrix layer to prevent re-infection.

A collagen scaffold for the delivery of bioactive agents such as antimicrobials comprising a first collagen matrix layer and a second collagen matrix layer in which the first collagen matrix layer comprises a first bioactive agent physically entrapped in the first collagen matrix layer and the second collagen matrix layer comprises a second bioactive agent chemically attached to the second collagen matrix layer for an initial high concentration elution of antimicrobial from the first collagen matrix layer followed by a sustained release from the second collagen matrix layer to prevent re-infection.

A collagen scaffold for the delivery of bioactive agents such as antimicrobials comprising a first collagen matrix layer and a second collagen matrix layer in which the first collagen matrix layer comprises a first bioactive agent physically entrapped in the first collagen matrix layer and the second collagen matrix layer comprises a second bioactive agent chemically attached to the second collagen matrix layer for an initial high concentration elution of antimicrobial from the first collagen matrix layer followed by a sustained release from the second collagen matrix layer to prevent re-infection.

Disclosed are 3D-printed scaffolds having high bone cement content, and in particular, high hydroxyapatite (HA) content. The disclosed methods and compositions provide the ability to print biocompatible scaffolds having patient-specific geometries with controlled porosity, microstructure, osteoconductivity, and mechanical strength. The scaffolds may be used for in vitro and in vivo craniofacial and dental applications.

Disclosed are 3D-printed scaffolds having high bone cement content, and in particular, high hydroxyapatite (HA) content. The disclosed methods and compositions provide the ability to print biocompatible scaffolds having patient-specific geometries with controlled porosity, microstructure, osteoconductivity, and mechanical strength. The scaffolds may be used for in vitro and in vivo craniofacial and dental applications.

A tendon/ligament repair implant for treatment of tears or lesions of tendons and ligaments, including capsular reconstruction, and compositions for delivering calcium and/or phosphate ions in combination with a collagen solution that can be placed between soft tissue and bone to facilitate healing of the soft tissue-bone interface are provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that complement current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation, or, in situations where the native tissue cannot be repaired tensile properties that provide for substitution of the native tissue selected porosity and longitudinal pathways for tissue in-growth; and may include an at least partially bioabsorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time. The compositions can be pre-dried into a thin sheet of material and delivered as a pre-formed matrix, or as a gel or paste which sets in place to form the matrix between the soft tissue and bone.

A tendon/ligament repair implant for treatment of tears or lesions of tendons and ligaments, including capsular reconstruction, and compositions for delivering calcium and/or phosphate ions in combination with a collagen solution that can be placed between soft tissue and bone to facilitate healing of the soft tissue-bone interface are provided. The implant may incorporate features of rapid deployment and fixation by arthroscopic means that complement current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation, or, in situations where the native tissue cannot be repaired tensile properties that provide for substitution of the native tissue selected porosity and longitudinal pathways for tissue in-growth; and may include an at least partially bioabsorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time. The compositions can be pre-dried into a thin sheet of material and delivered as a pre-formed matrix, or as a gel or paste which sets in place to form the matrix between the soft tissue and bone.

A composition for bone regeneration includes substantially spherical granules. Each of the spherical granules include an outer shell including magnesium phosphate and nano-sized silica and a bioactive core encapsulated by the outer shell. The granules include macro-pores and micro-pores. The macro-pores are intergranular spaces between adjacent granules, and the micro-pores are intragranular nanopores formed on the outer shell of each of the granules. A method of producing the substantially spherical granules, includes providing a mixture of a biological active powder, magnesium phosphate, and an initiator with a colloidal silica solution; rotating the mixture with dual asymmetric centrifugation for a predetermined amount of time; and drying the resulting material.

A biocompatible structure includes a scaffold obtained from a 3D structure. The 3D structure includes base layered structures, each of which includes at least a first layer and a second layer surrounded by the first layer. The first layer includes at least one of first, second and third media. The second layer includes at least another of the first, second and third media. The first medium comprises bone particles. The second medium comprises a polymer dissolvable in a first solvent. The third medium comprises solid particulates dissolvable in a second solvent different than the first solvent. The 3D structure is treated with the second solvent to dissolve the solid particulates so as to form pores at positions of the solid particulates therein, thereby resulting in the scaffold having a porosity adjustable by sizes of the solid particulates and concentration of the solid particulates in the 3D structure.

Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.