Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 μm to 800 μm. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.

Disclosed herein are threads of cross-linked hyaluronic acid and hydroxyapatite, the precursor compositions from which they are prepared and processes for their manufacturing.

Disclosed herein are threads of cross-linked hyaluronic acid and hydroxyapatite, the precursor compositions from which they are prepared and processes for their manufacturing.

The present invention relates to an absorbable biomedical composite material and a preparation method therefor, wherein the absorbable biomedical composite material comprises: a substrate particle containing a calcium phosphate compound; an intermediate layer which is coated on the surfaces of the substrate particle and has a first glass transition temperature, the first glass transition temperature being not higher than a normal body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The present invention can provide an absorbable biomedical composite material which not only increases the mechanical strength but also improves the toughness.

The present invention relates to an absorbable biomedical composite material and a preparation method therefor, wherein the absorbable biomedical composite material comprises: a substrate particle containing a calcium phosphate compound; an intermediate layer which is coated on the surfaces of the substrate particle and has a first glass transition temperature, the first glass transition temperature being not higher than a normal body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The present invention can provide an absorbable biomedical composite material which not only increases the mechanical strength but also improves the toughness.

The present invention relates to an absorbable biomedical composite material and a preparation method therefor, wherein the absorbable biomedical composite material comprises: a substrate particle containing a calcium phosphate compound; an intermediate layer which is coated on the surfaces of the substrate particle and has a first glass transition temperature, the first glass transition temperature being not higher than a normal body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The present invention can provide an absorbable biomedical composite material which not only increases the mechanical strength but also improves the toughness.

The present invention relates to an absorbable biomedical composite material and a preparation method therefor, wherein the absorbable biomedical composite material comprises: a substrate particle containing a calcium phosphate compound; an intermediate layer which is coated on the surfaces of the substrate particle and has a first glass transition temperature, the first glass transition temperature being not higher than a normal body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The present invention can provide an absorbable biomedical composite material which not only increases the mechanical strength but also improves the toughness.

The present invention relates to an absorbable biomedical composite material and a preparation method therefor, wherein the absorbable biomedical composite material comprises: a substrate particle containing a calcium phosphate compound; an intermediate layer which is coated on the surfaces of the substrate particle and has a first glass transition temperature, the first glass transition temperature being not higher than a normal body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The present invention can provide an absorbable biomedical composite material which not only increases the mechanical strength but also improves the toughness.

The present invention relates to an absorbable biomedical composite material and a preparation method therefor, wherein the absorbable biomedical composite material comprises: a substrate particle containing a calcium phosphate compound; an intermediate layer which is coated on the surfaces of the substrate particle and has a first glass transition temperature, the first glass transition temperature being not higher than a normal body temperature; and a polymer matrix which is formed on the outer surface of the intermediate layer and has a second glass transition temperature, the second glass transition being higher than the first glass transition temperature. The present invention can provide an absorbable biomedical composite material which not only increases the mechanical strength but also improves the toughness.

The current invention relates to a composition for parenteral administration comprising a canine plasma and hyaluronic acid or a salt or ester thereof, wherein said plasma comprises lipids and/or phospholipids. The inventions also relates to a kit comprising one or more aliquots of a composition, said composition comprising a canine plasma comprising lipids and/or phospholipids and hyaluronic acid or a derivative thereof and optionally one or more pharmaceutical active ingredients, wherein said kit further comprises one or more aliquots of a calcium source, preferably a calcium chloride solution. The invention also pertains to the composition and kit of current invention for use in the treatment of musculoskeletal diseases.