A bone implant is provided which includes a plurality of lyophilized porous macroparticles comprising ceramic material and collagen. The plurality of lyophilized porous macroparticles is coated with a mineral coating which comprises nano-size features having a carbonate-substituted, calcium-deficient hydroxyapatite component, the bone implant comprising a plurality of recesses, projections, or a combination thereof. A method of making the bone implant and a method of treating a bone defect with the bone implant are also provided.

A bone implant is provided which includes a plurality of lyophilized porous macroparticles comprising ceramic material and collagen. The plurality of lyophilized porous macroparticles is coated with a mineral coating which comprises nano-size features having a carbonate-substituted, calcium-deficient hydroxyapatite component, the bone implant comprising a plurality of recesses, projections, or a combination thereof. A method of making the bone implant and a method of treating a bone defect with the bone implant are also provided.

A method of generating a bioceramic-containing biomaterial-derived thermoplastic extrusion is provided. The method includes combining a bioceramic-containing solid with at least one thermoplastic resin, wherein the bioceramic-containing solid is uniformly dispersed in the resin. The method further includes extruding the bioceramic-containing solid included in the resin to create a net shape. The net shape is selected from a group consisting of a filament, a pellet, a bar, a molding, and a three-dimensional printing material stock.

A method of generating a bioceramic-containing biomaterial-derived thermoplastic extrusion is provided. The method includes combining a bioceramic-containing solid with at least one thermoplastic resin, wherein the bioceramic-containing solid is uniformly dispersed in the resin. The method further includes extruding the bioceramic-containing solid included in the resin to create a net shape. The net shape is selected from a group consisting of a filament, a pellet, a bar, a molding, and a three-dimensional printing material stock.

The present invention provides protein-polymer conjugates, and methods for generating biocompatible scaffolds formed of hydrogels comprising the conjugates and use of the scaffolds for tissue regeneration. The present invention provides improved processes for the preparation of the conjugates, wherein the conjugates of the invention are preferably produced in an environmentally friendly process avoiding polar organic solvents.

The present invention provides protein-polymer conjugates, and methods for generating biocompatible scaffolds formed of hydrogels comprising the conjugates and use of the scaffolds for tissue regeneration. The present invention provides improved processes for the preparation of the conjugates, wherein the conjugates of the invention are preferably produced in an environmentally friendly process avoiding polar organic solvents.

Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

The present invention relates to a system for producing artificial osseous tissue comprising: a client computer acquiring an image information of a subject bone tissue from an imaging unit that picks up an image of a subject bone tissue of a patient to generate a 3D image information; a server computer identifying the subject bone tissue based on the image information of the subject bone tissue received from the client computer, generating a 3D image information of at least one therapeutic bone tissue model corresponding to the subject bone tissue, and transmitting the 3D image information of the at least one therapeutic bone tissue model to the client computer; and a machining unit for fabricating an artificial bone tissue based on the 3D image information of the therapeutic bone tissue model determined from the server computer.