Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 m to 800 m. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.

Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 m to 800 m. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.

An implantable composition is provided. The composition comprises porous ceramic granules. The porous ceramic granules comprise hydroxyapatite in an amount of about 8 to about 22 wt. % and beta-tricalcium phosphate in an amount of about 78 to about 92 wt. % based on a total weight of a ceramic granule. The composition includes a collagen carrier, and the porous ceramic granules have an average diameter from about 50 m to 800 m. Methods of making are also disclosed.

An implantable composition is provided. The composition comprises porous ceramic granules. The porous ceramic granules comprise hydroxyapatite in an amount of about 8 to about 22 wt. % and beta-tricalcium phosphate in an amount of about 78 to about 92 wt. % based on a total weight of a ceramic granule. The composition includes a collagen carrier, and the porous ceramic granules have an average diameter from about 50 m to 800 m. Methods of making are also disclosed.

This invention is directed to a shaped block, a dental implant abutment comprising an implant, an abutment and a shaped block, wherein the shaped block comprises a dried collagen matrix; and a method of preparation thereof.

This invention is directed to a shaped block, a dental implant abutment comprising an implant, an abutment and a shaped block, wherein the shaped block comprises a dried collagen matrix; and a method of preparation thereof.

This invention is directed to a shaped block, a dental implant abutment comprising an implant, an abutment and a shaped block, wherein the shaped block comprises a dried collagen matrix; and a method of preparation thereof.

A bone regeneration material has a cotton-wool like structure formed of a plurality of electrospun fibers that contain bound BMP-2 through -TCP binding peptide. The electrospun biodegradable fiber contains 25-65 vol % of -TCP particles distributed in the fiber such that a portion of the -TCP particles is exposed on a surface of the electrospun fiber and the remaining portion of the -TCP particles is buried in the fiber. -TCP binding peptides that are fused with BMP-2 are bound to the -TCP particles so that BMP-2 is tethered to -TCP particles on the surface of the fibers. Upon implantation of the bone regeneration material in a bone defect site of a human body, BMP-2 that are tethered to -TCP particles on the surface of the bone regeneration material promotes proliferation and differentiation of cells at the bone defect site.

A bone regeneration material has a cotton-wool like structure formed of a plurality of electrospun fibers that contain bound BMP-2 through -TCP binding peptide. The electrospun biodegradable fiber contains 25-65 vol % of -TCP particles distributed in the fiber such that a portion of the -TCP particles is exposed on a surface of the electrospun fiber and the remaining portion of the -TCP particles is buried in the fiber. -TCP binding peptides that are fused with BMP-2 are bound to the -TCP particles so that BMP-2 is tethered to -TCP particles on the surface of the fibers. Upon implantation of the bone regeneration material in a bone defect site of a human body, BMP-2 that are tethered to -TCP particles on the surface of the bone regeneration material promotes proliferation and differentiation of cells at the bone defect site.

The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.