The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.

The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.

The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.

Implant comprising composite powder with microstructured particles, obtained by a process in which large particles are bonded to small particles, wherein the large particles have a mean particle diameter in the range from 10 m to 10 mm, the large particles comprise at least one polymer, the small particles are arranged on the surface of the large particles and/or are non-homogeneously spread within the large particles, the small particles comprise a calcium salt, the small particles have a mean particle size in the range from 0.01 m to 1.0 mm,
wherein the particles of the composite powder have a mean particle size d50 in the range from 10 m to less than 200 m and the fine fraction of the composite powder is less than 50 vol %.

Therefore, the subject matter of the invention further are implants obtained by selective laser sintering of a composition comprising a composite powder, especially as an implant for applications in the field of neuro, oral, maxillary, facial, ear, nose and throat surgery as well as of hand, foot, thorax, costal and shoulder surgery.

Implant comprising composite powder with microstructured particles, obtained by a process in which large particles are bonded to small particles, wherein the large particles have a mean particle diameter in the range from 10 m to 10 mm, the large particles comprise at least one polymer, the small particles are arranged on the surface of the large particles and/or are non-homogeneously spread within the large particles, the small particles comprise a calcium salt, the small particles have a mean particle size in the range from 0.01 m to 1.0 mm,
wherein the particles of the composite powder have a mean particle size d50 in the range from 10 m to less than 200 m and the fine fraction of the composite powder is less than 50 vol %.

Therefore, the subject matter of the invention further are implants obtained by selective laser sintering of a composition comprising a composite powder, especially as an implant for applications in the field of neuro, oral, maxillary, facial, ear, nose and throat surgery as well as of hand, foot, thorax, costal and shoulder surgery.

Process for engineering instant nanoporous bio-artificial bone tissue composite is designed aiming the prevention of body immune reaction when integrated with host bone tissue and also reduces its period of integration. This nanoporous biocomposite is compounded by a number of ingredients. Hydroxylapatite (HA), or/and alpha- or beta-tricalcium phosphate (- or -TCP). Polycaprolactone (PCL) or polylactic acid (PLA). Any gelatinable solution or gel, then water is added in relevant quantity for producing gel or injectable solution of this biocomposite. Any substance composed of any connective collagen tissue. Recombinant Human Vascular Endothelial Growth Factor. Any kind of acrylate when the hardening and final process of all this compound is acquired immediately by ultrasound treatment.

Process for engineering instant nanoporous bio-artificial bone tissue composite is designed aiming the prevention of body immune reaction when integrated with host bone tissue and also reduces its period of integration. This nanoporous biocomposite is compounded by a number of ingredients. Hydroxylapatite (HA), or/and alpha- or beta-tricalcium phosphate (- or -TCP). Polycaprolactone (PCL) or polylactic acid (PLA). Any gelatinable solution or gel, then water is added in relevant quantity for producing gel or injectable solution of this biocomposite. Any substance composed of any connective collagen tissue. Recombinant Human Vascular Endothelial Growth Factor. Any kind of acrylate when the hardening and final process of all this compound is acquired immediately by ultrasound treatment.

A synthetic bead is for implantation within the body of an animal or human body. The bead includes a surface defining a shape having a bulk volume of the bead. The surface of the bead is coated with at least a first therapeutic agent to form an inner layer; and an outer layer includes a biodegradable polymer and a second therapeutic agent positioned above the inner layer.

A synthetic bead is for implantation within the body of an animal or human body. The bead includes a surface defining a shape having a bulk volume of the bead. The surface of the bead is coated with at least a first therapeutic agent to form an inner layer; and an outer layer includes a biodegradable polymer and a second therapeutic agent positioned above the inner layer.

The present invention relates to settable compositions for use in surgery. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable compositions.