Compositions for forming porous materials and three-dimensional objects, including fibers, films and coatings made from the materials are provided. Also provided are methods for forming the porous objects from the compositions. The compositions include a solvent, a polymer binder that is soluble in the solvent, and solid particles that are insoluble in the solvent. The solid particles include water-soluble salt particles that can be selectively dissolved from objects made from the compositions to render the resulting structures porous.

The present disclosure relates to a composite filler comprising: porous inorganic particles including a sintered body of calcium-based particles and pores distributed in the sintered body; and a biodegradable carrier, and a product including the same.

The present disclosure relates to a composite filler comprising: porous inorganic particles including a sintered body of calcium-based particles and pores distributed in the sintered body; and a biodegradable carrier, and a product including the same.

A method for producing a cotton-wool like material for bone regeneration using a wet spinning method. 50-80 wt % of calcium salt particles and 50-20 wt % of PDLLGA resin are put into a mixing vessel, dissolved in acetone, and stirred to produce a spinning solution with a resin concentration of 10-20 wt % in which said calcium salt particles are dispersed. The produced spinning solution is filled in a syringe, and the spinning solution filled in the syringe is injected into a collector container filled with poor solvent by extruding the spinning solution from the discharge port of an injection needle having a predetermined diameter. The spinning solution injected into the poor solvent is solidified into fibers by interdiffusion of desorption of organic solvent and penetration of poor solvent in the poor solvent solution. The fibers solidified in the poor solvent are deposited in a floating state in the collector vessel without fiber-to-fiber adhesion and collected in a cotton-wool like shape.

A method for producing a cotton-wool like material for bone regeneration using a wet spinning method. 50-80 wt % of calcium salt particles and 50-20 wt % of PDLLGA resin are put into a mixing vessel, dissolved in acetone, and stirred to produce a spinning solution with a resin concentration of 10-20 wt % in which said calcium salt particles are dispersed. The produced spinning solution is filled in a syringe, and the spinning solution filled in the syringe is injected into a collector container filled with poor solvent by extruding the spinning solution from the discharge port of an injection needle having a predetermined diameter. The spinning solution injected into the poor solvent is solidified into fibers by interdiffusion of desorption of organic solvent and penetration of poor solvent in the poor solvent solution. The fibers solidified in the poor solvent are deposited in a floating state in the collector vessel without fiber-to-fiber adhesion and collected in a cotton-wool like shape.

A composition for producing a bone replacement material, which composition reacts with water or an aqueous solution in a cementitious setting reaction and forms a solid body. Additionally disclosed is a method for producing a pharmaceutical excipient having the aforementioned composition, the pharmaceutical excipient produced in this way, and the use of such a composition or such a pharmaceutical excipient for the local release of at least one pharmaceutical active ingredient.

A composition for producing a bone replacement material, which composition reacts with water or an aqueous solution in a cementitious setting reaction and forms a solid body. Additionally disclosed is a method for producing a pharmaceutical excipient having the aforementioned composition, the pharmaceutical excipient produced in this way, and the use of such a composition or such a pharmaceutical excipient for the local release of at least one pharmaceutical active ingredient.

The invention relates to calcium hydroxyapatite particles having been sintered at a certain temperature range and which are not treated at a temperature above this range. Furthermore, the present invention relates to an injectable composition comprising such particles and to uses thereof. Surprisingly, it was found that the particles of the invention are superior over calcium hydroxyapatite particles known in the art with respect to bio-stimulation.

The invention relates to calcium hydroxyapatite particles having been sintered at a certain temperature range and which are not treated at a temperature above this range. Furthermore, the present invention relates to an injectable composition comprising such particles and to uses thereof. Surprisingly, it was found that the particles of the invention are superior over calcium hydroxyapatite particles known in the art with respect to bio-stimulation.

The present disclosure provides a fiber membrane and a preparation method and use thereof, and belongs to the field of biological materials. The fiber membrane includes a fiber with a core-shell structure, where a core of the fiber includes simvastatin and a first spinnable polymer, and a shell of the fiber includes hydroxyapatite and a second spinnable polymer. In the fiber, a release of the simvastatin mainly depends on a rate of water invasion. After water invades the fiber, the simvastatin in the fiber leaves the fiber with the diffusion of water. In the present disclosure, a barrier function of the shell prevents moisture from entering the core. Therefore, the simvastatin in the core cannot leave the fiber with the diffusion of water molecules in an early stage, and a release rate of drugs is slowed down in the early stage, thereby controlling sustained release of the drugs.