A method for 3D printing a patient-specific bone implant having variable density, in various aspects, comprises: (1) providing a thermoplastic polymer composition comprising: (A) between about 20% and about 50% bioactive agent by weight; (B) between about 0.5% and about 10% chemical foaming agent by weight; and (C) balance structural polymer by weight; (2) receiving, by computing hardware, a scan of a bone, the scan comprising at least a 3D image of the bone and radiodensity data for the bone; and (3) causing, by the computing hardware, a 3D printer to form the patient-specific bone implant from the 3D image using the thermoplastic polymer by modifying a 3D printing temperature of the 3D printer during printing of the patient-specific bone implant such that each portion of the patient-specific bone implant is produced at a temperature that corresponds to a desired density defined by the radiodensity data for the bone.

Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into osteoblasts capable of forming bone. Devices and methods described include exposing a stem cell source, such as bone marrow aspirate, adipose tissue and/or purified allogenic stem cells, to an active agent, in a manner effective to form activated stem cells.

Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into osteoblasts capable of forming bone. Devices and methods described include exposing a stem cell source, such as bone marrow aspirate, adipose tissue and/or purified allogenic stem cells, to an active agent, in a manner effective to form activated stem cells.

A spinal implant body 100, including a body volume 101 having an inferior portion 102A, a superior portion 102B, and a central portion 102C disposed between the inferior and superior portions 102A, 102B. The body 100 further includes a first bioactive polymer portion 117A distributed throughout body volume 101, a second bioactive ceramic portion 120A distributed throughout the body volume 101, and a third interconnected pore network portion 105A (which may be filled with a fourth fugitive portion 140A) distributed throughout the body volume 101. The central portion 102C is less porous than the inferior and superior portions 102A, 102B and the pores in the inferior portion 102A are on average larger than the pores in the central portion 102C.

A spinal implant body 100, including a body volume 101 having an inferior portion 102A, a superior portion 102B, and a central portion 102C disposed between the inferior and superior portions 102A, 102B. The body 100 further includes a first bioactive polymer portion 117A distributed throughout body volume 101, a second bioactive ceramic portion 120A distributed throughout the body volume 101, and a third interconnected pore network portion 105A (which may be filled with a fourth fugitive portion 140A) distributed throughout the body volume 101. The central portion 102C is less porous than the inferior and superior portions 102A, 102B and the pores in the inferior portion 102A are on average larger than the pores in the central portion 102C.

A spinal implant body 100, including a body volume 101 having an inferior portion 102A, a superior portion 102B, and a central portion 102C disposed between the inferior and superior portions 102A, 102B. The body 100 further includes a first bioactive polymer portion 117A distributed throughout body volume 101, a second bioactive ceramic portion 120A distributed throughout the body volume 101, and a third interconnected pore network portion 105A (which may be filled with a fourth fugitive portion 140A) distributed throughout the body volume 101. The central portion 102C is less porous than the inferior and superior portions 102A, 102B and the pores in the inferior portion 102A are on average larger than the pores in the central portion 102C.

An implant for treating a bone defect wherein the implant comprises osteoconductive supporting bodies and an insertion aid. The insertion aid is designed for insertion of the osteoconductive supporting bodies into a bone defect and for holding together the osteoconductive supporting bodies. Also disclosed is a kit comprised of an implant for treating a bone defect.

The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.

The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.

Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.