To provide a ceramic particle separable composite material having a calcium phosphate sintered body particle with which bioaffinity reduction and solubility change are suppressed as much as possible and which has a smaller particle diameter.

A ceramic particle separable composite material comprising a ceramic particle and a substrate, wherein: the ceramic particle and the substrate are chemically bonded to each other, or the ceramic particle physically adheres to or is embedded in the substrate; the ceramic particle has a particle diameter within a range of 10 nm to 700 nm; the ceramic particle is a calcium phosphate sintered body particle; and the ceramic particle contains no calcium carbonate.

The invention relates to compositions useful for bone repair and methods of preparing the same. The invention is particularly suitable for bone repair of large bone defects. In an aspect of the invention, the compositions comprise a biocompatible polymer and a clay that form a scaffold. In a further aspect of the invention, the multiple scaffolds can be configured together to form scaffold blocks.

The invention relates to compositions useful for bone repair and methods of preparing the same. The invention is particularly suitable for bone repair of large bone defects. In an aspect of the invention, the compositions comprise a biocompatible polymer and a clay that form a scaffold. In a further aspect of the invention, the multiple scaffolds can be configured together to form scaffold blocks.

Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.

Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.

Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.

Provided are gene-activated materials comprising a scaffold and at least one nucleic acid molecule which may be chemical bound together or in which the at least one nucleic acid is not bound but coated on a surface of the scaffold. Methods for regenerating bone using these gene-activated materials are also provided.

Provided are gene-activated materials comprising a scaffold and at least one nucleic acid molecule which may be chemical bound together or in which the at least one nucleic acid is not bound but coated on a surface of the scaffold. Methods for regenerating bone using these gene-activated materials are also provided.

The curdlan-based biomaterial containing P-1,3-glucan (curdlan), whey protein isolate (WPI) and hydroxyapatite ceramics (HAp), where the proportions of polymer components to 100 ml of aqueous solution are respectively: 6-20% (w/v)P-1,3-glucan, 20-50% (w/v)whey protein isolate (WPI), while the amount of added hydroxyapatite ceramic granules (HAp) to such a polymer mixture is 40 g-100 g. and a method of producing the biphasic biomaterial consisting in that a 20-50% (w/v) aqueous solution of whey protein isolate (WPI), preferably 30% (w/v), is added to the P-1,3-glucan powder (curdlan), so as to obtain a mixture in which the concentration of curdlan in relation to the WPI solution is 6-20% (w/v), preferably 8% (w/v).

The curdlan-based biomaterial containing P-1,3-glucan (curdlan), whey protein isolate (WPI) and hydroxyapatite ceramics (HAp), where the proportions of polymer components to 100 ml of aqueous solution are respectively: 6-20% (w/v)P-1,3-glucan, 20-50% (w/v)whey protein isolate (WPI), while the amount of added hydroxyapatite ceramic granules (HAp) to such a polymer mixture is 40 g-100 g. and a method of producing the biphasic biomaterial consisting in that a 20-50% (w/v) aqueous solution of whey protein isolate (WPI), preferably 30% (w/v), is added to the P-1,3-glucan powder (curdlan), so as to obtain a mixture in which the concentration of curdlan in relation to the WPI solution is 6-20% (w/v), preferably 8% (w/v).