The present invention relates to an in-vivo bulking agent which can be used as a medicinal agent for prevention or treatment of at least one disease selected from the group consisting of urinary incontinence, fecal incontinence, and gastroesophageal reflux or as a filler for use in a plastic surgery procedure, and to a preparation method therefor. The in-vivo bulking agent can exhibit a bulking effect when injected into the body and particularly, is highly biocompatible because a first composition in which silicone particles are coated with a zwitterionic polymer having a surfactant property is introduced into a second composition, whereby the bulking agent can inhibit inflammatory reactions in vivo.

A cell delivery device and a method of producing a three dimensional device which is vascularized when implanted or topologically applied to human or animal body. Cell laden hydrogel (cells mixed with hydrogel) is casted or injected or 3D bioprinted in a leaf-like form, which contains removable parts (templates). After crosslinking, the templates are removed and the channel for vascularization is created. The device is ready for use in vitro or in vivo.

A cell delivery device and a method of producing a three dimensional device which is vascularized when implanted or topologically applied to human or animal body. Cell laden hydrogel (cells mixed with hydrogel) is casted or injected or 3D bioprinted in a leaf-like form, which contains removable parts (templates). After crosslinking, the templates are removed and the channel for vascularization is created. The device is ready for use in vitro or in vivo.

A cell delivery device and a method of producing a three dimensional device which is vascularized when implanted or topologically applied to human or animal body. Cell laden hydrogel (cells mixed with hydrogel) is casted or injected or 3D bioprinted in a leaf-like form, which contains removable parts (templates). After crosslinking, the templates are removed and the channel for vascularization is created. The device is ready for use in vitro or in vivo.

The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.

The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.

A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

There is provided a composition for forming an artificial skin that can shorten the cross-linking time while maintaining excellent application performance and coating performance.

A composition for forming an artificial skin of the present disclosure comprises a first agent and a second agent, wherein the first agent comprises: (a) a polymer A composed of one or more organopolysiloxanes containing at least two carbon-carbon double bonds or at least one carbon-carbon triple bond in the molecule; (b) a polymer B composed of one or more organopolysiloxanes containing at least two Si—H units in the molecule; and (c) a silicone having a viscosity of 1.5 mPa.Math.s or less at 25° C., and wherein the second agent comprises a catalyst that promotes cross-linking of the polymer A and the polymer B.

There is provided a composition for forming an artificial skin that can shorten the cross-linking time while maintaining excellent application performance and coating performance.

A composition for forming an artificial skin of the present disclosure comprises a first agent and a second agent, wherein the first agent comprises: (a) a polymer A composed of one or more organopolysiloxanes containing at least two carbon-carbon double bonds or at least one carbon-carbon triple bond in the molecule; (b) a polymer B composed of one or more organopolysiloxanes containing at least two Si—H units in the molecule; and (c) a silicone having a viscosity of 1.5 mPa.Math.s or less at 25° C., and wherein the second agent comprises a catalyst that promotes cross-linking of the polymer A and the polymer B.