Described herein are gelatin nanoparticles including their use in a composition. The composition may comprise a plurality of gelatin nanoparticles, at least one polymer, and water. In some embodiments, the composition comprises cells. The composition may be in the form of a hydrogel. Methods of using such gelatin nanoparticles and/or compositions are also described.

The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.

The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.

The invention relates to an implant preform made of plastic, which comprises an assembly of at least one biocompatiblebeing intended for contact with a biological materialthermoplastic plastics unit (A) having an elasticity modulus E.sub.A and at least one thermoplastic plastics unit (B) having an elasticity modulus E.sub.B, where for the elasticity moduli of these plastics units E.sub.A<E.sub.B, and the plastics units in their assembly zone are seamlessly connected thermally to one another. The invention also relates to the production of the implant preform made of plastic and also to the use of the implant preform as an implant or for fabrication of an implant therefrom, more particularly to the use thereof as a dental implant or for fabrication of a dental implant. The invention can also be applied to other bone implants.

The invention relates to an implant preform made of plastic, which comprises an assembly of at least one biocompatiblebeing intended for contact with a biological materialthermoplastic plastics unit (A) having an elasticity modulus E.sub.A and at least one thermoplastic plastics unit (B) having an elasticity modulus E.sub.B, where for the elasticity moduli of these plastics units E.sub.A<E.sub.B, and the plastics units in their assembly zone are seamlessly connected thermally to one another. The invention also relates to the production of the implant preform made of plastic and also to the use of the implant preform as an implant or for fabrication of an implant therefrom, more particularly to the use thereof as a dental implant or for fabrication of a dental implant. The invention can also be applied to other bone implants.

The invention relates to an implant preform made of plastic, which comprises an assembly of at least one biocompatiblebeing intended for contact with a biological materialthermoplastic plastics unit (A) having an elasticity modulus E.sub.A and at least one thermoplastic plastics unit (B) having an elasticity modulus E.sub.B, where for the elasticity moduli of these plastics units E.sub.A<E.sub.B, and the plastics units in their assembly zone are seamlessly connected thermally to one another. The invention also relates to the production of the implant preform made of plastic and also to the use of the implant preform as an implant or for fabrication of an implant therefrom, more particularly to the use thereof as a dental implant or for fabrication of a dental implant. The invention can also be applied to other bone implants.

A bone void filler material is provided for sustained release of a therapeutic agent. The bone void filler material comprising a biodegradable matrix having ceramic cement beads comprising calcium sulfate, and ceramic particles disposed within the matrix. The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.

A bone void filler material is provided for sustained release of a therapeutic agent. The bone void filler material comprising a biodegradable matrix having ceramic cement beads comprising calcium sulfate, and ceramic particles disposed within the matrix. The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.

A bone void filler material is provided for sustained release of a therapeutic agent. The bone void filler material comprising a biodegradable matrix having ceramic cement beads comprising calcium sulfate, and ceramic particles disposed within the matrix. The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.

Biocompatible hybrid fibrous scaffold, derived from a synthetic polymer and a natural hydrogel, and methods of use thereof in tissue engineering.