Conjugates of fibrinogen and a plurality of curable groups covalently attached thereto, and curable formulations comprising such conjugates, are provided. Also provided are three-dimensional objects (scaffolds) made of the conjugate or the curable formulation, for example, by additive manufacturing, and uses thereof in, for example, tissue healing and/or regeneration.

Composite nerve guides for nerve regeneration are provided, wherein the composite guide comprise a nerve graft and a nerve conduit continuing an active agent that promote axon regeneration. The devices can provide structural supports to guide nerve regeneration and locally deliver an active agent (e.g., glial cell-line derived neurotrophic factor (GDNF) and/or glial growth factor 2 (GGF2) to injured nervous system tissue upon implantation in a subject. Methods of treatment using such devices are also provided.

Composite nerve guides for nerve regeneration are provided, wherein the composite guide comprise a nerve graft and a nerve conduit continuing an active agent that promote axon regeneration. The devices can provide structural supports to guide nerve regeneration and locally deliver an active agent (e.g., glial cell-line derived neurotrophic factor (GDNF) and/or glial growth factor 2 (GGF2) to injured nervous system tissue upon implantation in a subject. Methods of treatment using such devices are also provided.

This invention is directed to polymer-permeated grafts, including those which contain an active which provide for the controlled or sustained release thereof, and methods of making and using the same.

This invention is directed to polymer-permeated grafts, including those which contain an active which provide for the controlled or sustained release thereof, and methods of making and using the same.

A nano-zinc oxide-supported bacterial cellulose microfiber-alginate fiber composite is described. The composite is obtained by absorbing nano-zinc oxide-supported bacterial cellulose microfibers on an alginate fiber spunlace non-woven fabric; the nano-zinc oxide is uniformly distributed on the surface of the bacterial cellulose microfibers. This composite has good biocompatibility, mechanical properties and water absorption properties, and has a great application prospect in biomedical fields, such as wound dressings, human body repair materials, tissue engineering materials, etc.

A nano-zinc oxide-supported bacterial cellulose microfiber-alginate fiber composite is described. The composite is obtained by absorbing nano-zinc oxide-supported bacterial cellulose microfibers on an alginate fiber spunlace non-woven fabric; the nano-zinc oxide is uniformly distributed on the surface of the bacterial cellulose microfibers. This composite has good biocompatibility, mechanical properties and water absorption properties, and has a great application prospect in biomedical fields, such as wound dressings, human body repair materials, tissue engineering materials, etc.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.